Publications related to Primary care

ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly

It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of the laboratory-based science, clinical trials and qualitative research that were presented during the 2 ...

EUROPEAN RESPIRATORY SOC JOURNALS LTD2023

Different health systems-Different mortality outcomes? Regional disparities in avoidable mortality across German-speaking Europe, 1992-2019

Mathias Lerch

Background: Evaluating the impact of health systems on premature mortality across different countries is a very challenging task, as it is hardly possible to disentangle it from the influence of contextual factors such as cultural differences. In this resp ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Deep learning diagnostic and severity-stratification for interstitial lung diseases and chronic obstructive pulmonary disease in digital lung auscultations and ultrasonography: clinical protocol for an observational case-control study

Mary-Anne Hartley, Jonathan Dönz

BackgroundInterstitial lung diseases (ILD), such as idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive pulmonary disorders with a poor prognosis. Prom ...

BMC2023

Technology-Enabled Collaborative Care for Concurrent Diabetes and Distress Management During the COVID-19 Pandemic: Protocol for a Mixed Methods Feasibility Study

Sean Lewis Hill

Background: The COVID-19 pandemic disrupted the delivery of diabetes care and worsened mental health among many patients with type 2 diabetes (T2D). This disruption puts patients with T2D at risk for poor diabetes outcomes, especially those who experience ...

JMIR PUBLICATIONS, INC2023

Detection of Spatiotemporal Clusters of COVID-19-Associated Symptoms and Prevention Using a Participatory Surveillance App: Protocol for the @choum Study

Stéphane Joost, Idris Guessous, David Nicolas De Ridder

Background: The early detection of clusters of infectious diseases such as the SARS-CoV-2-related COVID-19 disease can promote timely testing recommendation compliance and help to prevent disease outbreaks. Prior research revealed the potential of COVID-19 ...

JMIR PUBLICATIONS, INC2021

New Measurement Method in Drug Sensing by Direct Total-Charge Detection in Voltammetry

Sandro Carrara, Danilo Demarchi, Simone Aiassa, José David González Martínez

Electrochemical biosensors are promoting point-of-care and wearable instrumentation due to their high versatility in measuring human metabolites. There is a considerable number of biological compounds that can be detected and measured through voltammetry b ...

IEEE2020

Wearable multi-electrode platform for ion sensing

Francesca Criscuolo

With the growth of personalized medicine and e-Health, there has been an increasing interest in the development of accurate sensing systems able to support this healthcare revolution for both in- and off-hospital monitoring. Remote biosensing devices can d ...

EPFL2020

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Johan Auwerx, Patrick Aebischer, Pénélope Andreux, Dongryeol Ryu, Frederic Burdet, Anurag Singh

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we adm ...

NATURE PUBLISHING GROUP2019

Assessment of menstrual health status and evolution through mobile apps for fertility awareness

Marcel Salathé, Laura Symul

For most women of reproductive age, assessing menstrual health and fertility typically involves regular visits to a gynecologist or another clinician. While these evaluations provide critical information on an individual's reproductive health status, they ...

Springer2019

Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice

Scott Anthony Lindner, Matthias Wolf, Jingjing Jiang, Markus Rudin

Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Microdevice-integrated immunoassays for Point-of-Care Therapeutic Drug Monitoring

Elena-Diana Bojescu

A significant number of drugs exhibit narrow therapeutic windows and high inter-individual pharmacokinetic variability. In such cases, Therapeutic Drug Monitoring (TDM) is compulsory in order to optimize the efficacy of the drug while avoiding adverse effe ...

EPFL2018

Highly Modular Bioluminescent Sensors for Small Molecules and Proteins

Kai Johnsson, Rudolf Griss, Alberto Schena, Qiuliyang Yu

Obtaining patient-specific information through the quantification of small molecules and proteins in bodily fluids is essential for personalized therapies. Point-of-care (POC) diagnostic devices hold the promise of delivering such benefit to a wide range o ...

Elsevier Academic Press Inc2017

Ultra-Low Power Ion-Sensing Smart Platform for Noninvasive Healthcare Applications

Mihai Adrian Ionescu, Erick Antonio Garcia Cordero, Hoël Maxime Guérin, Francesco Bellando, Amira Muhech Medrano

The development of nanotechnologies, and the advent of micro/nano-sensors with novel functionalities integrated on flexible substrates, has opened the way to the development of wearable technology. Interest in wearable technology comes from the considerabl ...

2016

Lanthanide light for biology and medical diagnosis

Jean-Claude Bünzli

Optical imaging emerges as a vital component of the various techniques needed to meet the stringent requirements of modern bioanalysis and bioimaging. Lanthanide luminescent bioprobes (LLBs) have greatly contributed to this field during the past 35 years b ...

Elsevier Science Bv2016

Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI

Wietske Van der Zwaag, Melissa Saenz, Stephanie Clarke

Environmental sounds are highly complex stimuli whose recognition depends on the interaction of top-down and bottom-up processes in the brain. Their semantic representations were shown to yield repetition suppression effects, i. e. a decrease in activity d ...

Public Library of Science2015

A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Theophile Mande, Francisco Javier Perez Saez, Yeli Mariam Sou, Marino Gatto

We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly acco ...

Public Library of Science2015

Label-free Analytics by Transmission Localized-SPR and its Application to Small Molecules Monitoring in Serum

Giulia Cappi

In the frame of therapeutic drug monitoring and personalized medicine, point-of-care systems (POCs) that can help overcome long waiting times for results and costly procedures of clinical tests are highly desirable. At present, the detection of low-molecul ...

EPFL2014

Perceived efficiency impacts following electronic health record implementation: An exploratory study of an urban community health center network

Purpose: Faced with an increasingly complex patient population and growing demand for services, community health centers (CHCs) are recognizing that electronic health records (EHRs) may help their efforts to improve efficiency in care delivery. Yet little ...

2010

Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Jacopo Olivo, Luca Benini

Drug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitori ...

IEEE2008

Satisfaction des utilisateurs du dossier patient informatisé valaisan

Philippe Wieser, David Marey

A multidisciplinary and shared computerized patient record (CPR) has been progressively implemented since 2002 for all public hospitals in the State of Valais, Switzerland. This paper presents the results of a formal evaluation of user’s satisfaction ...

2006