Concept

Lipid signaling

Related publications (23)

Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis

Ursula Röthlisberger, Pablo Campomanes Ramos, Andrea Cavalli, Giulia Palermo, Marilisa Neri

The serine hydrolase, fatty acid amide hydrolase (FAAH), is responsible for the intracellular degradation of anandamide and other bioactive fatty acid ethanolamides involved in the regulation of pain, inflammation, and other pathophysiological processes. T ...

Amer Chemical Soc2013

Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels

Howard Riezman

Glycosylphosphatidylinositol (GPI) anchor biosynthesis takes place in the endoplasmic reticulum (ER). After protein attachment, the GPI anchor is transported to the Golgi where it undergoes fatty acid remodeling. The ER exit of GPI-anchored proteins is con ...

2012

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both munc13 and protein kinase C

Ralf Schneggenburger, Natalya Korogod

Diacylglycerol (DAG) and phorbol esters strongly potentiate transmitter release at synapses by activating protein kinase C (PKC) and members of the Munc13 family of presynaptic vesicle priming proteins. This PKC/Munc13 pathway has emerged as a crucial regu ...

Society for Neuroscience2008