Publications related to Inner ear

Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

Simon Nessim Henein, Charles Baur, Loïc Benoît Tissot-Daguette

Surgeons generally assess the mobility of the ossicle chain by manual palpation using rigid elongated hooks inserted through the ear canal. As the applied forces are in the range of a few grams equivalent force, the measurement remains subjective and its r ...

IEEE2021

Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

Oxford University Press2021

Repeat stereotactic radiosurgery for progressive vestibular schwannomas after previous radiosurgery: a systematic review and meta-analysis

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

Vestibular schwannomas (VS) are slow-growing intracranial extraaxial benign tumors, developing from the vestibular part of the eight cranial nerves. Stereotactic radiosurgery (SRS) has now a long-term scientific track record as first intention treatment fo ...

SPRINGER2021

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Flight of mind: Sensorimotor and multisensory embodiment with aviation robotics, flight simulator, and virtual reality

Myeong Seop Song

Normally, humans experience an 'I' as residing in one's body and as the agent of one's actions. In other words, the self is experienced as being inside the body (self-location), as having a body (self-identification), and as being able to control the perso ...

EPFL2020

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas

Constantin Tuleasca

BackgroundSchwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Kn ...

2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

2019

Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber

Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Eirini Kakkava, Donald Benjaman Conkey, Marilisa Romito

We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the p ...

OPTICAL SOC AMER2019

Bulged Eardrum Detection From 3D Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

Bulging is a medical characteristic of the eardrum that is crucial for the diagnosis of acute otitis media. This work proposes a novel classification method for distinguishing bulged eardrums from non-bulged ones. The method uses novel key features extract ...

IEEE2018

Multisensory interactions in peripersonal space and their contributions to bodily self-consciousness

Petr Grivaz

What is the relevance of the body and body-transformed sensory information for subjective experience? In the last two decades, paradigms from cognitive neuroscience have demonstrated that the subjective sensations of possessing a body (body ownership, BO), ...

EPFL2017

Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

Demetri Psaltis, Simon Nessim Henein

Objective: To enable development of an endoscope for cellular-level optical imaging of the inner ear. Study Design: A prospective study of 50 cadaveric human temporal bones to define detailed surgical anatomy of the round window (RW) region and the range o ...

Lippincott, Williams & Wilkins2016

Vestibular Processing and its Cortical Signature in Humans

Steven Gale

The vestibular system encodes rotations and translations of the head in space. While much is known about cortical processing of the classical Aristotelian sensory modalities, such as vision and touch, knowledge of how vestibular stimulation is encoded in t ...

EPFL2015

The vestibular system: a spatial reference for bodily self-consciousness

Olaf Blanke, Andrea Serino, Christian Pfeiffer

Self-consciousness is the remarkable human experience of being a subject: the “I”. Self- consciousness is typically bound to a body, and particularly to the spatial dimensions of the body, as well as to its location and displacement in the gravitational fi ...

Frontiers Research Foundation2014

Nobel Prize centenary: Robert Barany and the vestibular system

Olaf Blanke, Christophe Lopez

The hundredth anniversary of Robert Barany's Nobel Prize in Medicine offers the opportunity to highlight the importance of his discoveries on the physiology and pathophysiology of the vestibular organs. Barany developed the method of caloric vestibular sti ...

Cell Press2014

Active Control mitigating the Ear Canal Occlusion Effect caused by Hearing Aids

Thomas Stefan Zurbrügg

The World Health Organization (WHO) estimates the prevalence of a disabling hearing loss to be above 5% world-wide 1. A treatment with a hearing aid - be it behind-the-ear (BTE), in-the-ear (ITE) or receiver-in-canal (RIC) - involves some degree of occlusi ...

EPFL2014

Investigations on the physical factors influencing the ear canal occlusion effect caused by hearing aids

Hervé Lissek, Thomas Stefan Zurbrügg

The occlusion effect refers to the altered perception of one's own voice when the ear canal is fully or partially obstructed. While the loudness increase due to body conducted sounds requires an assessment by psychoacoustic methods, the ratio of sound pres ...

Hirzel Verlag2014

Imagined own-body transformations during passive self-motion

Olaf Blanke, Michiel van Elk

Spatial perspective taking is a crucial social skill that underlies many of our everyday interactions. Previous studies have suggested that spatial perspective taking is an embodied process that involves the integration of both motor and proprioceptive inf ...

2014

Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis

Demetri Psaltis, Ye Pu, Ye Pu, Chia-Lung Hsieh, Xin Yang

Sensorineural hearing loss is the most common type of hearing loss worldwide, yet the underlying cause is typically unknown because the inner ear cannot be biopsied today without destroying hearing, and intracochlear cells have not been imaged with resolut ...

SPIE Society of Photo-optical Instrumentation Engineers2013