Publications related to Sensitivity and specificity

Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge

Jean-Philippe Thiran, Gabriel Girard, Erick Jorge Canales Rodriguez, Juan Luis Villarreal Haro, Alessandro Daducci, Alonso Ramirez Manzanares, Marco Pizzolato, Ying-Chia Lin, Sara Sedlar, Caio Seguin, Kenji Marshall, Yang Ji

Estimating structural connectivity from diffusion-weighted magnetic resonance imaging is a challenging task, partly due to the presence of false-positive connections and the misestimation of connection weights. Building on previous efforts, the MICCAI-CDMR ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Kamiar Aminian, Anisoara Ionescu, Abolfazl Soltani, Francesca Salis

Background: Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparatively assess and validat ...

BioMed Central2023

Review on Uric Acid Recognition by MOFs with a Future in Machine Learning

Shaswati Mandal

Uric acid (UA) is produced from purine metabolism and serves as a prevalent biomarker for multiple diseases including cancer. Hyperuricemia or hypouricemia can cause multiple dysfunctions throughout the biological processes. Consequently, there is a pressi ...

Amer Chemical Soc2023

A Comparison of Residual-based Methods on Fault Detection

Olga Fink, Gaëtan Michel Frusque

An important initial step in fault detection for complex industrial systems is gaining an understanding of their health condition. Subsequently, continuous monitoring of this health condition becomes crucial to observe its evolution, track changes over tim ...

PHM Society2023

Tailoring the Hybridization Density of DNA Biosensors through Tunable Surface Functionalization

Sandrine Gerber, Mounir Driss Mensi, Pauline Skigin, Perrine Agnes Edith Robin, Lucas Mayoraz

DNA biosensors are promising candidates for the development of point-of-care diagnosis methods. They can be inserted in microfluidic platforms, are often non-expensive, and can be produced for a variety of targeted analytes. However, their development face ...

Wiley-VHCA AG2023

Design and Preparation of Sensing Surfaces for Capacitive Biodetection

Sandrine Gerber, Perrine Agnes Edith Robin

Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfac ...

2023

Evaluation and optimization of novel extraction algorithms for the automatic detection of atrial activations recorded within the pulmonary veins during atrial fibrillation

Jean-Marc Vesin, Adrian Luca, Yann Prudat, Sasan Yazdani, Etienne Pruvot

Background and objective The automated detection of atrial activations (AAs) recorded from intracardiac electrograms (IEGMs) during atrial fibrillation (AF) is challenging considering their various amplitudes, morphologies and cycle length. Activation time ...

BMC2022

The progressive loss of brain network fingerprints in Amyotrophic Lateral Sclerosis predicts clinical impairment

Enrico Amico, Antonella Romano

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by functional connectivity alterations in both motor and extra-motor brain regions. Within the framework of network analysis, fingerprinting represents a reliable approach to ...

ELSEVIER SCI LTD2022

Robust design using multiobjective optimisation and artificial neural networks with application to a heat pump radial compressor

Jürg Alexander Schiffmann, Soheyl Massoudi, Cyril Picard

Although robustness is an important consideration to guarantee the performance of designs under deviation, systems are often engineered by evaluating their performance exclusively at nominal conditions. Robustness is sometimes evaluated a posteriori throug ...

2022

Wastewater monitoring outperforms case numbers as a tool to track COVID-19 incidence dynamics when test positivity rates are high

Tamar Kohn, Xavier Fernandez Cassi, Joseph Chadi Benoit Lemaitre, Federica Cariti, Alex Tunas Corzon, Timothy R. Julian, Carola Bänziger

Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, case numbers may be underreported, whereas wastewater does not suffer from this li ...

2021

Hierarchical Microstructure Informed Tractography

Gabriel Girard, Alessandro Daducci, Maxime Descoteaux

Background: Tractography uses diffusion magnetic resonance imaging to noninvasively infer the macroscopic pathways of white matter fibers and it is the only available technique to probe in vivo the structural connectivity of the brain. However, despite thi ...

MARY ANN LIEBERT, INC2021

High Sensitivity Detection of a Solubility Limiting Surface Transformation of Drug Particles by DNP SENS

David Lyndon Emsley, Arthur César Pinon, Jasmine Viger-Gravel

We investigate the presence of a surface species for the active pharmaceutical ingredient (API) AZD9496 with dynamic nuclear polarization surface enhanced nuclear spectroscopy (DNP SENS). We show that using DNP we can elucidate the presence of an amorphous ...

2021

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Vassily Hatzimanikatis, Georgios Fengos, Tuure Eelis Hameri

Background Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc re ...

BMC2021

Automatic locking of a parametrically resonating, base-excited, nonlinear beam

Amit Yedidia Dolev

Described is a closed-loop control scheme capable of stabilizing a parametrically excited nonlinear structure in several vibration modes. By setting the relative phase between the spatially filtered response and the excitation, the open-loop unstable solut ...

SPRINGER2021

Experimental characterisation of textile compaction response: A benchmark exercise

Véronique Michaud, Baris Çaglar, Christophe Lopez

This paper reports the results of an international benchmark exercise on the measurement of fibre bed compaction behaviour. The aim was to identify aspects of the test method critical to obtain reliable results and to arrive at a recommended test procedure ...

2021

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

Sylvie Roke, Claire Jacqueline Léa Teulon, Ali Yasin Sonay, Shahed Behzadi, Sine Yaganoglu

Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they ...

2021

Comparison of autofluorescence and white-light bronchoscopies performed with the Evis Lucera Spectrum for the detection of bronchial cancers: a meta-analysis

Georges Wagnières, Xiuwei Zhang, Li Wang, Yang Yang

Background: Many recent studies have reported that autofluorescence bronchoscopy (AFB) has a superior sensitivity and decreased specificity in the diagnosis of bronchial cancers when compared with white-light bronchoscopy (WLB). We specifically analyzed th ...

AME PUBL CO2020

Shake Table Blind Prediction Tests: Contributions for Improved Fiber-based Frame Modelling

João Saraiva Esteves Pacheco de Almeida

Distributed plasticity Euler-Bernoulli fiber beams are regularly used by researchers and practitioners to simulate the nonlinear seismic response of reinforced concrete framed structures. This study presents a sensitivity analysis, combining newly proposed ...

2020

Dissipative-coupling-assisted laser cooling: Limitations and perspectives

Alexander Tagantsev

The recently identified possibility of ground-state cooling of a mechanical oscillator in the unresolved sideband regime by combination of the dissipative and dispersive optomechanical coupling under the red sideband excitation [Phys. Rev. A 88, 023850 (20 ...

AMER PHYSICAL SOC2020

Applying SHARK-X to perform data assimilation with the LWR-PROTEUS Phase II integral experiments

Andreas Pautz, Daniel Jerôme Siefman, Mathieu Hursin

Data assimilation methods have recently been implemented in the sensitivity analysis and uncertainty quantification tool SHARK-X. This paper presents how they were used with sensitivity coefficients and randomly-sampled nuclear data to simulate integral pa ...

PERGAMON-ELSEVIER SCIENCE LTD2020