Publications related to Diabetic retinopathy

The role of the visual field size in artificial vision

Objective. Artificial vision has been and still is the subject of intense research. The ultimate goal is to help blind people in their daily life. Approaches to artificial vision, including visual prostheses and optogenetics, have strongly focused on resto ...

IOP Publishing Ltd2023

OCT-angiography assessing quiescent and active choroidal neovascularization in retinitis pigmentosa associated with PRPH2 pathogenic variant

Imen Habibi

Purpose: To report multimodal imaging findings including optical coherence tomography angiography (OCT-A) of a patient presenting with a quiescent choroidal neovascularization (CNV) in one eye and an active CNV in the fellow eye, complicating retinitis pig ...

2021

Ophthalmic system and method for clinical device using transcleral illumination with multiple points source

Christophe Moser, Timothé Laforest, Mathieu Künzi

An ophthalmic illumination and imaging system with transscleral / transpalpebral illumination of the eye fundus comprises a light-delivering device with a plurality of emitting areas; each of the emitting areas being configured to be independently controll ...

2020

Design optimization of Miniature Magnetorheological Valves with Self-Sensing Capabilities Used for a Wearable Medical Application

Yves Perriard, Yoan René Cyrille Civet, Sofia Lydia Ntella, Minh Trung Duöng

Magnetorheological (MR) fluids are materials characterized as “intelligent” since their rheological properties may be controlled by the excitation of an external magnetic field. The application of the latter brings the fluid from a liquid to a semi-solid s ...

IEEE2020

Outcome and Complications of Combined Modified Deep Sclerectomy and Trabeculectomy for Surgical Management of Glaucoma: A Pilot Study

André Mermoud, Sylvain Roy

Purpose: To report the outcome and complications of a combined surgical technique of modified deep sclerectomy and trabeculectomy (mDST) for glaucoma. Patients and Methods: Retrospective study of 44 eyes of 43 patients with open and closed angle glaucoma w ...

2020

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Rolf Gruetter, Hongxia Lei

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Wiley-Blackwell2020

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons

Marion Leleu, Gioele La Manno, Pierre Raymond Fabre

Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here ...

2019

Decoding Neural Metabolic Markers From the Carotid Sinus Nerve in a Type 2 Diabetes Model

Silvestro Micera

Recent studies showed that the carotid sinus nerve (CSN) and the sympathetic nervous system (SNS) are overactivated in type 2 diabetes and that restoring the correct CSN neural activity can re-establish the proper metabolism. However, a robust characteriza ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

Design, Modelling and Sensing Possibilities of Magneto-Rheological Based Devices

Daniel Grivon

This thesis has been put in place during the development of an innovative medical device which consists in an intelligent footwear for foot plantar pressure redistribution in diabetic patients. In fact, despite the several sophisticated techniques develope ...

EPFL2017

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

Johan Auwerx, Hongbo Zhang

The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears ...

Elsevier2016

Detection of hypoglycemic events through wearable sensors

Karl Aberer, Jean Paul Calbimonte Perez, Jean-Eudes Marie Ranvier

Diabetic patients are dependent on external substances to balance their blood glucose level. In order to control this level, they historically needed to sample a drop a blood from their hand and have it analyzed. Recently, other directions emerged to offer ...

CEUR-WS2016

Novel ADAM9 homozygous mutation in a consanguineous Egyptian family with severe cone-rod dystrophy and cataract

Tatiana Favez

Objective To genetically and phenotypically describe a new ADAM9 homozygous mutation in a consanguineous family from Egypt with autosomal recessive cone-rod dystrophy (arCRD), anterior polar and posterior subcapsular cataract. Design, setting and participa ...

Bmj Publishing Group2014

Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa

Purpose: To study the influence of retinal structural changes on oxygen saturation in retinitis pigmentosa (RP) patients. Methods: Oximetry measurements were performed on 21 eyes of 11 RP patients and compared to 24 eyes of 12 controls. Retinal oxygen satu ...

Wiley-Blackwell2014

Cone-Rod Dystrophy Caused by a Novel Homozygous RPE65 Mutation in Leber Congenital Amaurosis

Background: The aim of this study was to describe an unexpected phenotype in a family with Leber congenital amaurosis (LCA) due to a retinal pigment epithelium-specific protein 65 kDa (RPE65) homozygous mutation. History and Signs: We analyzed a family fro ...

Georg Thieme Verlag Kg2014

Angiogenesis inhibition by the maleimide-based small molecule GNX-686

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

We investigated the anti-angiogenic properties of GNX-686, a newly identified maleimide-based small molecule. In vitro studies on HUVEC showed that GNX-686 inhibited cell growth with an ED50 of 20-25 mu M, while human HeLa tumor cells and non-transformed e ...

Elsevier2012

Pattern Dystrophy With High Intrafamilial Variability Associated With Y141C Mutation In The Peripherin/Rds Gene And Successful Treatment Of Subfoveal Cnv Related To Multifocal Pattern Type With Anti-Vegf (Ranibizumab) Intravitreal Injections

Objective: To identify disease causing mutation in three generations of a Swiss family with pattern dystrophy and high intrafamilial variability of phenotype. To assess the effect of intravitreal ranibizumab injections in the treatment of subfoveal choroid ...

Lippincott Williams & Wilkins2012

Acute Hypoglycemia Induces Retinal Cell Death in Mouse

Martine Emery

Background: Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic excursions could lead to cardiovascular disease, nephropathy, neuropathy and retinopathy. ...

Public Library of Science2011

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Pascal Escher

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors. The nucle ...

Public Library of Science2011

Extracellular matrix in angiogenesis: dynamic structures with translational potential

Jeffrey Alan Hubbell

The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune func ...

2011