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Related publications (29)

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses

Maria Reva

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synap-tic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger rel ...

CELL PRESS2022

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Adrien Michel Achille Devresse, Hugo Thabo Dictus, Matthias Wolf, Felix Schürmann, Daniel Keller, Werner Alfons Hilda Van Geit, Pramod Shivaji Kumbhar, Alexis Arnaudon, Jean-Denis Georges Emile Courcol, András Ecker, Juan Bautista Hernando Vieites, Michael Emiel Gevaert, Huanxiang Lu, Liesbeth Maria L Vanherpe, Cyrille Pierre Henri Favreau, Vishal Sood, Sirio Bolaños Puchet, Ran Levi, James Bryden Isbister, Judit Planas Carbonell, Daniela Egas Santander, Joni Henrikki Herttuainen, Samuel Lieven D. Lapere, Christoph Pokorny, Thomas Brice Delemontex, Nicolas René Jean Ninin, Juan Luis Riquelme Roman, Alexander Dietz, Benoît Jean-Albert Coste, Gianluca Ficarelli,

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

Nagammal Neelagandan

In the neocortex, functionally distinct areas process specific types of information. Area identity is established by morphogens and transcriptional master regulators, but downstream mechanisms driving area-specific neuronal specification remain unclear. He ...

eLIFE SCIENCES PUBL LTD2022

Disruption of layer-specific visual processing in a model of focal neocortical epilepsy

Silvestro Micera, Matteo Vissani

The epileptic brain is the result of a sequence of events transforming normal neuronal populations into hyperexcitable networks supporting recurrent seizure generation. These modifications are known to induce fundamental alterations of circuit function and ...

OXFORD UNIV PRESS INC2022

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

Hilal Lashuel, Nicolas Jean Philippe Guex, Christian Iseli, Anne-Laure Mahul Mellier, Jonathan Jean-Pierre Ricci, Yllza Jasiqi, Anass Chiki, Sean Michael Deguire, Ritwik Burai, Melek Firat Altay, Salvatore Novello, Sonia Donzelli, Ramanath Narayana Hegde, Pedro José Santana Ribeiro Magalhães

Antibodies against phosphorylated alpha-synuclein (aSyn) at 5129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson's disease and other neurodegenerative dis ...

NATURE PORTFOLIO2022

Epigenetic plasticity as a signature for memory allocation

Giulia Santoni

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

EPFL2022

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

James Gonzalo King, Suraj Honnuraiah

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...

2022

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Marie-Isabelle Guillot de Suduiraut, Ioannis Zalachoras, Mandy Meijer

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

2022

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Carl Petersen, Sylvain Crochet, Tanya C Sippy

The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...

OXFORD UNIV PRESS2021

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Janis Lazovskis

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024