Covers sustaining proliferation in cancer cells, growth factors, receptor tyrosine kinases, signal transduction, viral oncogenes, and therapeutic opportunities.
Explores programmed cell death mechanisms, including apoptosis and autophagy, with a focus on their implications in various organisms and regeneration processes.
Explores cellular senescence mechanisms induced by mitogenic signals, DNA damage, and oncogenes, emphasizing the role of key regulatory proteins and the impact on cell division.
Examines how a receptor regulates proteostasis in C. elegans, emphasizing the importance of maintaining cellular function and preventing protein misfolding diseases.
Explores drug targets, particularly nuclear receptors like PPARy and pregnane X receptor, and their impact on endocrine signaling and drug pharmacokinetics.
