Publications related to Lethal dose

Satellite-Based Personal UV Dose Estimation

Epidemiology and public health research relating to solar ultraviolet (UV) exposure usually relies on dosimetry to measure UV doses received by individuals. However, measurement errors affect each dosimetry measurement by unknown amounts, complicating the ...

2021

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

Emmanuelle Ines Flatt

This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field. In the first two chapters, we studied longitudinally t ...

EPFL2021

Update on yesterday's dose-Use of delivery log-files for daily adaptive proton therapy (DAPT)

Marco Matter

In daily adaptive proton therapy (DAPT), the treatment plan is re-optimized on a daily basis. It is a straightforward idea to incorporate information from the previous deliveries during the optimization to refine this daily proton delivery. A feedback sign ...

2020

Impact of the skull contour definition on Leksell Gamma Knife(R)Icon (TM) radiosurgery treatment planning

Constantin Tuleasca

Introduction The Gamma Knife(R)planning software (TMR 10, Elekta Instruments, AB, Sweden) affords two ways of defining the skull volume, the "historical" one using manual measurements (still perform in some centers) and the new one using image-based skull ...

2020

Establishment of a Therapeutic Ratio for Gamma Knife Radiosurgery of Trigeminal Neuralgia: The Critical Importance of Biologically Effective Dose Versus Physical Dose

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

OBJECTIVE: How variations of treatment time affect the safety and efficacy of Gamma Knife (GK) radiosurgery is a matter of considerable debate. With the relative simplicity of treatment planning for trigeminal neuralgia (TN), this question has been address ...

2020

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Johan Auwerx, Patrick Aebischer, Pénélope Andreux, Dongryeol Ryu, Frederic Burdet, Anurag Singh

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we adm ...

NATURE PUBLISHING GROUP2019

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

On the origin of primary 1/2 a(0) and a(0) loops in irradiated Fe(Cr) alloys

Robin Schäublin, Anna Prokhodtseva

The radiation-induced primary dislocation loops in thin foils of ultra-high purity Fe and Fe(Cr) model alloys were investigated using ion irradiation in situ in a TEM. In the '111 mechanism' the induced nanometric loops of type a(0) stem from mutual ...

Pergamon-Elsevier Science Ltd2017

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Raphaël Doenlen, François Bochud, Gael Luis Boivin

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate ...

Elsevier Ireland Ltd2017

Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh

Patrick Descombes

A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the ...

Wiley-Blackwell2017

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

John McKinney, Neeraj Dhar, François Signorino-Gelo

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

Elsevier Science Bv2016

Optimization of drug combinations using Feedback System Control

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

We describe a protocol for the discovery of synergistic drug combinations for the treatment of disease. Synergistic drug combinations lead to the use of drugs at lower doses, which reduces side effects and can potentially lead to reduced drug resistance, w ...

Nature Publishing Group2016

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Monitoring the post-irradiation E. coli survival patterns in environmental water matrices: Implications in handling solar disinfected wastewater

César Pulgarin, Stefanos Giannakis, Ana Isabel Merino Gamo

In this study, simulated solar disinfection of secondary effluent was followed by dark storage at different temperatures or different receiving water matrices. Escherichia coli illumination was followed by 3-day monitoring of the bacterial population and i ...

Elsevier2014

In vivo anti-tumor activity of the organometallic ruthenium(II)-arene complex [Ru(eta(6)-p-cymene)-Cl-2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Maxime Dubois

Based on the clinical success of platinum-based anti-cancer drugs such as cisplatin, carboplatin and oxaliplatin, a variety of other metal-based anti-cancer compounds are being investigated. In particular, a number of ruthenium-based compounds have been id ...

2014

Modelling oriented investigations of primary radiation damage in ultra high purity Fe and FeCr alloys

Anna Prokhodtseva

In the quest of the structural materials for the future fusion reactor, it has been shown that ferritic/martensitic (F/M) steels are very promising candidates, with a good radiation resistance in terms of damage accumulation in the microstructure relative ...

EPFL2013

The Insecticide Imidacloprid Causes Mortality of the Freshwater Amphipod Gammarus pulex by Interfering with Feeding Behavior

Kristin Schirmer

If an organism does not feed, it dies of starvation. Even though some insecticides which are used to control pests in agriculture can interfere with feeding behavior of insects and other invertebrates, the link from chemical exposure via affected feeding a ...

Public Library Science2013

Personalized Drug Administrations Using Support Vector Machine

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout

The decision-making process regarding drug dose, regularly used in everyday medical practice, is critical to patients’ health and recovery. It is a challenging process, especially for a drug with narrow therapeutic ranges, in which a medical doctor decides ...

2013

Chiasmatic Infiltration Secondary to Late Malignant Transformation of Retinoma

Alessia Pica

Purpose: To report the lethal course of malignant transformation of retinoma in an adult. Methods: Case report. A 40-year-old patient presented with retinoma in his right eye and retinoblastoma in his left eye. Enucleation was recommended but refused and t ...

Informa Healthcare2012

Helium-induced hardening effect in ferritic/martensitic steels F82H and Optimax-A irradiated in a mixed spectrum of high energy protons and spallation neutrons

Yong Dai

Ferritic/martensitic (FM) steels, F82H and Optimax-A, were irradiated up to 11.3 dpa/1175 appm He in Target-3 of the Swiss Spallation Neutron Source (SINQ). To investigate helium-induced hardening effect, micro-hardness and microstructure of the irradiated ...

Elsevier2011