Publications related to Vertebral artery dissection

Sensor-integrated ultraflexible endovascular devices

Medical interventions in the central nervous system (CNS) are challenging due to the complexity and delicacy of the brain tissue. Techniques that do not require opening the skull would alleviate patient discomfort and increase post-operative outputs. Vesse ...

EPFL2022

Estimation of the Lightning Performance of Overhead Lines Accounting for Different Types of Strokes and Multiple Strike Points

Farhad Rachidi-Haeri

Dealing with lightning performance computation, researchers usually consider only negative downward first return strokes and the relevant channel-base peak current distribution. The aim of this article is to account for the lightning flash mechanism, which ...

2021

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Oriane Poupart

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

EPFL2021

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Simon Jan Middendorp, Patrick Andreas Gonschorek, Christina Lamers

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

Nature Research2020

Stereotactic Gamma Knife Radiosurgery for Extracranial Arteriovenous Malformations

Constantin Tuleasca

Introduction: Head and neck extracranial arteriovenous malformations (AVMs) are rare pathological conditions which pose diagnostic and reconstruction challenges. Stereotactic radiosurgery (SRS) is nowadays an established treatment method for brain AVMs, wi ...

2020

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

Lydia Aslanidou

In a number of cardiovascular diseases, the paucity of longitudinal human data hinders our understanding of disease evolution and forestalls the discovery of new therapeutic strategies. We therefore heavily rely on animal models to elucidate the mechanisms ...

EPFL2019

Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

Nikolaos Stergiopoulos, Lydia Aslanidou, Bram Trachet, Goran Lovric, Mauro Ferraro, Patrick Segers

Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and ...

2019

Programmable Multistable Mechanisms for Safe Surgical Puncturing

Simon Nessim Henein, Charles Baur, Andrea Lovera, Ilan Vardi, Mohamed Gamal Abdelrahman Ahmed Zanaty, David Lambelet, Thomas Jean Julien Fussinger, Arno Rogg

We present novel medical devices for safe surgical puncturing, in particular a cannula for the treatment of retinal vein occlusion (RVO). This passive mechanical device has an adjustable stroke and exerts a puncturing force independent of operator applied ...

2019

Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice: from individual elastic lamella to 3D analysis

Nikolaos Stergiopoulos, Lydia Aslanidou, Bram Trachet, Marco Stampanoni, Patrick Segers

In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures in BAPN/AngII-infused mice, a mouse model for aortic dissection. Ascending and thoraco-a ...

Nature Research2018

Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

Nikolaos Stergiopoulos, Lydia Aslanidou, Jessica Sordet, Bram Trachet, Alessandra Piersigilli, Patrick Segers

Aims Angiotensin II-infused ApoE(-/-) mice are a popular mouse model for preclinical aneurysm research. Here, we provide insight in the often-reported but seldom-explained variability in shape of dissecting aneurysms in these mice. Methods and results N=45 ...

2017

Single trial prediction of self-paced reaching directions from EEG signals

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Eileen Lew Yi Lee

Early detection of movement intention could possibly minimize the delays in the activation of neuroprosthetic devices. As yet, single trial analysis using non-invasive approaches for understanding such movement preparation remains a challenging task. We st ...

Frontiers Research Foundation2014

Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms

Nikolaos Stergiopoulos, Philippe Reymond, Luca Augsburger

Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, ...

Springer US2011

Diffusion Spectrum Imaging after stroke shows structural changes in the contra-lateral motor network correlating with functional recovery

Jean-Philippe Thiran, Reto Meuli, Alessandro Daducci, Djalel Eddine Meskaldji, Gunnar Krüger, Cristina Granziera, Leila Cammoun, Xavier Gigandet

There is growing interest in understanding the role of the non-injured contra-lateral hemisphere in stroke recovery. In the experimental field, histological evidence has been reported that structural changes occur in the contra-lateral connectivity and cir ...

2011

Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives

Nikolaos Stergiopoulos, Mohamed Farhat, Philippe Reymond, Luca Augsburger, Edouard Fonck

With intracranial aneurysms disease bringing a weakened arterial wall segment to initiate, grow and potentially rupture an aneurysm, current understanding of vessel wall biology perceives the disease to follow the path of a dynamic evolution and increasing ...

2009

Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms

Nikolaos Stergiopoulos, Philippe Reymond

Haemodynamics is believed to play an important role in the initiation, growth and rupture of intracranial aneurysms. In this context, computational haemodynamics has been extensively used in an effort to establish correlations between flow variables and cl ...

2009

Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model - A report on the Virtual Intracranial Stenting Challenge 2007

Philippe Reymond, Luca Augsburger, Daniel Ruefenacht

This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented mode ...

2008