Publications related to Coronary catheterization

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

Arterial Wave Reflection and Aortic Valve Stenosis: Diagnostic Challenges and Prognostic Significance

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou

IntroductionArterial wave reflection is an important component of the left ventricular afterload, affecting both pressure and flow to the aorta. The aim of the present study was to evaluate the impact of wave reflection on transvalvular pressure gradients ...

FRONTIERS MEDIA SA2022

Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

Background. In people living with human immunodeficiency virus (HIV) (PLWH), individual polygenic risk scores (PRSs) are associated with coronary artery disease (CAD) events. Whether PRSs are associated with subclinical CAD is unknown. ...

OXFORD UNIV PRESS INC2022

Prognostic Implications of the Novel Pulmonary Hypertension Definition in Patients with Aortic Stenosis after Transcatheter Valve Replacement

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou

Introduction: Pulmonary hypertension (PH), traditionally defined as a mean pulmonary artery pressure (PAP) >= 25 mmHg, is associated with poor outcomes in patients undergoing a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). ...

MDPI2022

Predicting future myocardial infarction from angiographies with deep learning

Pascal Frossard, Emmanuel Abbé, Ortal Yona Senouf, Olivier Muller, Ntorina Thanou, Thabodhan Mahendiran, Omar Raita, Stéphane Fournier, David Meier, Nicolas Dayer, Farhang Aminfar

In patients with stable Coronary Artery Disease (CAD), the identification of lesions which will be responsible of a myocardial infarction (MI) during follow-up remains a daily challenge. In this work, we propose to predict culprit stenosis by applying a de ...

2021

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

Johan Auwerx, Hongwei Zhu, Yuan Liu, Yan Liu, Shuai Shao

Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that NCOR1 in macrophages plays important roles in metabolic regulation. However, the function of macrophage NCOR1 in response to myocard ...

2020

How Flow Reduction Influences the Intracranial Aneurysm Occlusion: A Prospective 4D Phase-Contrast MRI Study

Mohamed Farhat, Philippe Reymond, Pierre Bouillot

BACKGROUND AND PURPOSE: Flow-diverter stents are widely used for the treatment of wide-neck intracranial aneurysms. Various parameters may influence intracranial aneurysm thrombosis, including the flow reduction induced by flow-diverter stent implantation, ...

American Society of Neuroradiology (ASNR)2019

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

A computational fluid-structure interaction analysis of coronary Y-grafts

Alfio Quarteroni, Christian Vergara

Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphen ...

Elsevier Sci Ltd2017

Thin films for Healthcare Acquired Infections (HAIs) prevention : materials preparation, testing and characterization

Sami Rtimi

This thesis addresses the preparation of antibacterial surfaces for hospital facilities taking biomedical thin polymer films, textiles and catheter as probes. Magnetron sputtering is used to apply the coatings leading to fast bacterial inactivation in the ...

EPFL2016

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Laurent Descloux, Demetri Psaltis, Donald Benjaman Conkey, Thomas Jean Victor Marie Lanvin

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and ...

Spie-Int Soc Optical Engineering2015

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers

Nikolaos Stergiopoulos, Bryn Andrew Martin

Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no wid ...

Springer-Verlag2013

A method for the quantification of the pressure dependent 3D collagen configuration in the arterial adventitia

Nikolaos Stergiopoulos, Jelle Tymen Christiaan Schrauwen

Collagen plays an important role in the response of the arterial wall to mechanical loading and presumably has a load-bearing function preventing overdistension. Collagen configuration is important for understanding this role, in particular in mathematical ...

Elsevier2012

Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease

Jörg Hager

Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or Eastern Asian descent. Replication of ...

Public Library of Science2011

Fluid Structure Interaction Simulations of Physiological Blood Flow in the Aorta

Alfio Quarteroni, Nikolaos Stergiopoulos, Simone Deparis, Philippe Reymond, Paolo Crosetto, Dimitrios Kontaxakis

The numerical tools to simulate blood flow in the cardiovascular system are constantly developing due to the great clinical interest and to scientific advances in mathematical models and computational power. The present work aims to address and validate ne ...

Elsevier2011

Biomechanical, morphological and zero-stress state characterization of jugular vein remodeling in arteriovenous fistulas for hemodialysis

Nikolaos Stergiopoulos

While the role of hemodynamic variables on the development of intimal hyperplasia in arteriovenous fistulas for hemodialysis has been examined, less is known about the intramural biomechanical factors. In this study, arteriovenous fistulas were created by ...

2010

Extracellular matrix binding mixed micelles for drug delivery applications

Jeffrey Alan Hubbell, Davide Demurtas, Jutta Christine Wandrey

Received 5 January 2009 Accepted 22 March 2009 Available online 27 March 2009 Keywords: Mixed micelles Drug delivery Block copolymers Sirolimus Extracellular matrix We present the formation of collagen-binding mixed micelles and their potential suitability ...

2009

Nanostructured titania coatings for drug-eluting medical implants

Karin Dittmar

Medical implants delivering drugs are used to ensure efficient medication at body sites, at which the conventional administration of drugs is insufficient. The application of drug-delivery coatings is a beneficial concept for implants exposed to mechanical ...

EPFL2009

Nanostructured ceramic coating for deformable medical implants such as stents

Arnaud Tourvieille de Labrouhe

Coronary artery disease is one of the main causes of death in western countries. The standard of care has become the implantation of a coronary stent, i.e. a small metal-mesh tube reopening the lumen of the artery and maintaining the blood flow to the hear ...

EPFL2009

Nanostructured Ceramic Coatings for Drug Delivery

Heinrich Hofmann, Laurent-Dominique Piveteau, Arnaud Tourvieille de Labrouhe, Karin Dittmar

Drug eluting stents (DES) have been successfully implemented in clinical practice in the treatment against coronary artery disease. Compared to the implantation of bare metal stents, restenosis rates decreased significantly after stenting of DES into coron ...

Materials Research Society, 506 Keystone Drive, Warrendale, Pa 15086-7573 Usa2009