Publications related to Clinical neuropsychology

Resource-Efficient Continual Learning for Personalized Online Seizure Detection

David Atienza Alonso, Giovanni Ansaloni, José Angel Miranda Calero, Jonathan Dan, Amirhossein Shahbazinia, Flavio Ponzina

Epilepsy, a major neurological disease, requires careful diagnosis and treatment. However, the detection of epileptic seizures remains a significant challenge. Current clinical practice relies on expert analysis of EEG signals, a process that is time-consu ...

IEEE2024

Immersive VR for upper-extremity rehabilitation in patients with neurological disorders: a scoping review

Silvestro Micera, Elena Losanno

Background Neurological disorders, such as stroke and chronic pain syndromes, profoundly impact independence and quality of life, especially when affecting upper extremity (UE) function. While conventional physical therapy has shown effectiveness in provid ...

BioMed Central2024

Theta oscillations and minor hallucinations in Parkinson’s disease reveal decrease in frontal lobe functions and later cognitive decline

Olaf Blanke, Fosco Bernasconi

Cognitive decline and hallucinations are common and debilitating non-motor symptoms, usually occurring during later phases of Parkinson’s disease (PD). Minor hallucinations (MH) appear early in the disease course and have been suggested to predict cognitiv ...

2023

Corpus callosum structural characteristics in very preterm children and adolescents: Developmental trajectory and relationship to cognitive functioning

Dimitri Nestor Alice Van De Ville, Lorena Gonçalves de Alcântara e Freitas Krikler, Vanessa Siffredi

Previous studies suggest that structural alteration of the corpus callosum, i.e., the largest white matter commissural pathway, occurs after a preterm birth in the neonatal period and lasts across development. The present study aims to unravel corpus callo ...

ELSEVIER SCI LTD2023

EEG Spatiotemporal Patterns Underlying Self-other Voice Discrimination

Olaf Blanke, Pavo Orepic, Sixto Luis Alcoba Banqueri, Giannina Rita Iannotti, Thomas Koenig

There is growing evidence showing that the representation of the human “self” recruits special systems across different functions and modalities. Compared to self-face and self-body representations, few studies have investigated neural underpinnings specif ...

2021

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

Bénédicte Marie Maréchal, Jonas Richiardi, Christopher Clark

BackgroundTo assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology and predict clinical progression in a memory clinic setting.MethodsPlasma NfL and p-ta ...

2021

Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease

Kamiar Aminian, Arash Atrsaei

Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsuper ...

2021

Clinical value of assessing motor performance in postacute stroke patients

Kamiar Aminian, Anisoara Ionescu, Fabien Massé

Background Rehabilitative treatment plans after stroke are based on clinical examinations of functional capacity and patient-reported outcomes. Objective information about daily life performance is usually not available, but it may improve therapy personal ...

BioMed Central2021

Connectivity Measures Differentiate Cortical and Subcortical Sub-Acute Ischemic Stroke Patients

Silvestro Micera, Michael Lassi

Brain lesions caused by cerebral ischemia lead to network disturbances in both hemispheres, causing a subsequent reorganization of functional connectivity both locally and remotely with respect to the injury. Quantitative electroencephalography (qEEG) meth ...

FRONTIERS MEDIA SA2021

Real-world speed estimation using single trunk IMU: methodological challenges for impaired gait patterns

Kamiar Aminian, Anisoara Ionescu, Abolfazl Soltani

Walking speed (WS) is recognized as an important dimension of functional health and a candidate endpoint for clinical trials. To be adopted as a powerful outcome measure in clinical assessment, WS should be estimated pervasively and accurately in the real- ...

IEEE2020

Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes

Meritxell Bach Cuadra, Cristina Granziera, Guillaume Bonnier, Mario Joao Fartaria de Oliveira, Po-Jui Lu

Introduction:Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between (ii) changes in CL ...

FRONTIERS MEDIA SA2020

Depersonalization- and derealization-like phenomena of epileptic origin

Olaf Blanke, Lukas Heydrich, Nathaniel Evans

Objective Depersonalization refers to the sensation of being detached from one's body, often associated with feelings of loss of control over one's own body, actions, or thoughts. Derealization refers to the altered perception of one's surroundings that is ...

2019

Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis

Alessandra Griffa, Patric Hagmann, Kim Do

Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As oxidative stress is also linked to psychosis, it may interact with CT, leading to a more severe clinic ...

National Academy of Sciences2018

Modulation of vection latencies in the full-body illusion

Olaf Blanke, Bruno Herbelin, Alessandro Nesti, Giulio Rognini

Current neuroscientific models of bodily self-consciousness (BSC) argue that inaccurate integration of sensory signals leads to altered states of BSC. Indeed, using virtual reality technology, observers viewing a fake or virtual body while being exposed to ...

2018

Neuroprosthetics to support impaired hand functions: A multidisciplinary approach combining brain-machine interfaces and wearable exoskeletons

Luca Randazzo

Neuroprosthetics, the discipline that aims at interfacing neural systems to artificially engineered devices, has witnessed in recent years important advancements towards the ultimate goal of augmenting and restoring human functions through technology and a ...

EPFL2018

The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition

Nouchine Hadjikhani, Bogdan Draganski, Loyse Hippolyte, Borja Rodriguez Herreros

BACKGROUND: Deletions and duplications of the 16p11.2 BP4-BP5 locus are prevalent copy number variations (CNVs), highly associated with autism spectrum disorder and schizophrenia. Beyond language and global cognition, neuropsychological assessments of thes ...

Elsevier Science Inc2016

Improving emotional face perception in autism with diuretic bumetanide: A proof-of-concept behavioral and functional brain imaging pilot study

Nouchine Hadjikhani, Loyse Hippolyte, Ophélie Rogier, Torsten Ruest

Clinical observations have shown that GABA-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (Cl-)(i) and excitatory action of GABA. In a previous double-blind randomized study, we have shown ...

Sage Publications Ltd2015

The Brain Network reflecting Bodily Self-Consciousness: a functional connectivity study

Olaf Blanke, Roy Salomon, Roberto Martuzzi, Silvio Ionta

Several brain regions are important for processing self-location and first-person perspective, two important aspects of bodily self-consciousness. However, the interplay between these regions has not been clarified. In addition, while self-location and fir ...

Oxford Univ Press2014

Micro-Structural Brain Alterations in Aviremic HIV+ Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field

Tobias Kober, Reto Meuli, Alessandro Daducci, Djalel Eddine Meskaldji, Gunnar Krüger, Cristina Granziera, Alexis Roche, François Lazeyras

Objective Mild neurocognitive disorders (MND) affect a subset of HIV+ patients under effective combination antiretroviral therapy (cART). In this study, we used an innovative multi-contrast magnetic resonance imaging (MRI) approach at high-field to assess ...

Public Library of Science2013

Impaired Imagery for Upper Limbs

Olaf Blanke

The brain processes associated with mental imagery have long been a matter of debate. Neuroimaging and neuropsychological studies have yielded diverging evidence of mental transformation activating the right hemisphere, the left hemisphere, or both. Here, ...

Springer Verlag2009