Publications related to Paget's disease of bone

Age- and sex-specific normative values of bone mineral density in the adult glenoid

Dominique Pioletti, Alexandre Terrier, Alain Farron, Patrick Goetti, Frédéric Vauclair, Philippe Büchler

The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. We analyzed computed tomography (CT) scans of 441 shoulders ...

WILEY2022

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari, Tatiana Kochetkova

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

Sub-trabecular strain evolution in human trabecular bone

Goran Lovric, Alessandra Patera

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

NATURE RESEARCH2020

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Lakshmi Devi Chakkarapani

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

2020

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Dominique Pioletti, Ulrike Kettenberger, Jorge Solana Munoz

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

2018

Importance of trabecular anisotropy in finite element predictions of patellar strain after Total Knee Arthroplasty

Dominique Pioletti, Alexandre Terrier, Adeliya Latypova

Patellar fracture and anterior knee pain remain major complications after Total Knee Arthroplasty (TKA). Patient-specific finite element (FE) models should help improve understanding of these complications through estimation of joint and bone mechanics. Ho ...

Elsevier2017

Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites

Nicola Harris, Mario Michael Zaiss, Manuel Kulagin

Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severi ...

Taylor & Francis2017

Potential blindness in children of patients with hereditary bone disease

Mono- and bi-allelic mutations in the low-density lipoprotein receptor related protein 5 (LRP5) may cause osteopetrosis, autosomal dominant and recessive exudative vitreoretinopathy, juvenile osteoporosis, or persistent hyperplastic primary vitreous (PHPV) ...

Springer London Ltd2016

Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis

John Botsis, Joël Cugnoni, Marco Piccinini

Implanted rat bones play a key role in studies involving fracture healing, bone diseases or drugs delivery among other themes. In most of these studies the implants integration also depends on the animal daily activity and musculoskeletal loads, which affe ...

Elsevier2014

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Mario Michael Zaiss, Zhen Chen

Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism o ...

Amer Assoc Advancement Science2014

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Dominique Pioletti, Ulrike Kettenberger, Julien Ston

Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formati ...

Elsevier2014

Theoretical bounds for the influence of tissue-level ductility on the apparent-level strength of human trabecular bone

Frédéric Edouard Juillard

The role of tissue-level post-yield behavior on the apparent-level strength of trabecular bone is a potentially important aspect of bone quality. To gain insight into this issue, we compared the apparent-level strength of trabecular bone for the hypothetic ...

Elsevier Sci Ltd2013

Integration of mechanotransduction concepts in bone tissue engineering

Dominique Pioletti

Mechanical stimulus has been identified for a long time as a key player in the adaptation of the musculo-skeletal tissues to their function. Mechanical loading is then an intrinsic variable to be considered when new developments are proposed in bone tissue ...

Taylor & Francis2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Tamara Tanos, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Soft tissue artifact assessment during treadmill walking in subjects with total knee arthroplasty

Jean-Philippe Thiran, Kamiar Aminian, Arnaud Barré

Accurate measurement of knee kinematics during functional activities suffers mainly from soft tissue artifact (STA): the combination of local surface deformations and rigid movement of markers relative to the underlying bone (also called rigid STA movement ...

Ieee-Inst Electrical Electronics Engineers Inc2013

Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes

Harm-Anton Klok, Dusko Paripovic

Modification of bone implant materials with biofunctional surfaces that facilitate osteoblast adhesion and promote matrix mineralization is an attractive strategy to improve osseointegration. This manuscript discusses the preparation and properties of RGD ...

Royal Society of Chemistry2012

Role of damage mechanics in nanoindentation of lamellar bone at multiple sizes: Experiments and numerical modeling

Davide Carnelli

The aim of this paper is to show that damage mechanisms can account for the response of lamellar bone to nanoindentation tests, with particular regards to the decrease of indentation stiffness with increasing penetration depth and to the loss of contact st ...

2011

Multi-axial mechanical properties of human trabecular bone

Liliana Rincon Kohli

In the context of osteoporosis, evaluation of bone fracture risk and improved design of epiphyseal bone implants rely on accurate knowledge of the mechanical properties of trabecular bone. A multi-axial loading chamber was designed, built and applied to ex ...

2009

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini, Vincent Forster, Jean Hocké

A combined experimental/numerical study was performed to calculate the zone of highest strain in a rat tibia loaded axially. This study is motivated by the fact that the bone remodeling analysis in this in vivo rat model should be performed at the zone of ...

2009

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann, Francesco Merlini, Vincent Forster, Jean Hocké, Jensen Verhelle

A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed a ...

2009