Publications related to Stratified squamous epithelium

Using NanoSIMS coupled with microfluidics to visualize the early stages of coral infection by Vibrio coralliilyticus

Anders Meibom, Isabelle Domart-Coulon, Emma Mary Gibbin

Background: Global warming has triggered an increase in the prevalence and severity of coral disease, yet little is known about coral/pathogen interactions in the early stages of infection. The point of entry of the pathogen and the route that they take on ...

2018

Exploring the potency of normal and pathological human thymic epithelial cells

Tiphaine Mélodie Chantal Arlabosse

Thymic epithelial cells (TECs) are organised in a unique 3D network that is critical for the development of efficient and self-tolerant T-cells. We report for the first time that the human thymus of all ages, even old and involuted, contains a significant ...

EPFL2017

A balancing act between stratification and EMT in cultured human thymic epithelial cells

Matteo Pluchinotta

The thymus is the primary organ for T cell differentiation and maturation. Its stroma forms a characteristic sponge-like 3D structure mainly composed of thymic epithelial cells. Despite of this unconventional epithelial architecture, TECs express markers a ...

EPFL2016

Ice-covered Lake Onega: effects of radiation on convection and internal waves

Alfred Johny Wüest, Damien Bouffard, Natacha Tofield-Pasche

Early-spring under-ice convection in the Petrozavodsk Bay of Lake Onega (Russia) was investigated as part of an interdisciplinary research project conducted during March 2015. Measurements performed using a thermistor chain and vertical profiling sensors w ...

Springer Verlag2016

Neurogenin3 Initiates Stepwise Delamination of Differentiating Endocrine Cells During Pancreas Development

Anne Grapin-Botton, Mathieu Gouzi, Yung Hae Kim, Keiichi Katsumoto

During development, pancreatic endocrine cells are specified within the pancreatic epithelium. They subsequently delaminate out of the epithelium and cluster in the mesenchyme to form the islets of Langerhans. Neurogenin3 (Ngn3) is a transcription factor r ...

2011

Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

Yann Barrandon, Stéphanie Claudinot, Alessandro Wataru Amici, Paola Bonfanti

The thymus develops from the third pharyngeal pouch of the anterior gut and provides the necessary environment for thymopoiesis (the process by which thymocytes differentiate into mature T lymphocytes) and the establishment and maintenance of self-toleranc ...

2010

Stem cells of stratified epithelia : a generic stem cell?

Daniel-Alexandre Littman

Squamous stratified epithelia tissues are self-renewing, which quality implies the existence of stem cells. In skin the presence of bona fide multipotent stem cells has been demonstrated by long-term, serial grafting assays. We isolated, cultivated and exp ...

EPFL2008

Oligopotent stem cells are distributed throughout the mammalian ocular surface

Yann Barrandon, Ariane Rochat, Georges Abou Jaoudé

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty- five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal trans ...

2008

Thymic epithelial cells : relatives of multipotent stem cells of the skin

Paola Bonfanti

As primary lymphoid organ, the thymus provides the essential environment for maturation and selection of functional T lymphocytes. Thymic epithelial (TE) cells derive from the endoderm, and more specifically, from the third pharyngeal pouch. The thymic epi ...

EPFL2008

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells. To study Pten function in the intestine, we used various conditional transgenic strategies to specifically delete Pten from the m ...

2008

Two-dimensional impedance imaging of cell migration and epithelial stratification

Philippe Renaud, Yann Barrandon, Thomas Michael Braschler, Olof Pontus Linderholm, Jonas Vannod

We present a miniaturized impedance imaging system, developed for 2D imaging of cell and tissue culture. The system is based on 16 microelectrodes (5 µm × 4 mm). An equivalent circuit for four-point (tetrapolar) impedance spectra was developed and validate ...

2006

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

Melody Swartz, Boris Hinz

The differentiation of fibroblasts to contractile myofibroblasts, which is characterized by de novo expression of alpha-smooth muscle actin (alpha-SMA), is crucial for wound healing and a hallmark of tissue scarring and fibrosis. These processes often foll ...

Company of Biologists2005

Time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin and benzoporphyrin derivative monoacid ring A in the hamster model: comparative fluorescence microscopy study

Hubert van den Bergh, Georges Wagnières

The pharmacokinetics of the photosensitizer used play a key role in the understanding of the mechanism of photodynamic therapy-induced damage. Fluorescence microscopy was used to compare time-dependent biodistribution of tetra(m-hydroxyphenyl)chlorin (mTHP ...

2000

Photodynamic therapy of early squamous cell carcinoma with tetra(m-hydroxyphenyl)chlorin: optimal drug-light interval

Hubert van den Bergh, Georges Wagnières

The optimal drug-light interval for effective photodynamic therapy (PDT) of early squamous cell carcinomas was evaluated with tetra(m-hydroxyphenyl)chlorin (mTHPC) by means of two complementary modalities: irradiation tests and ex vivo fluorescence microsc ...

1997

Photodetection and photodynamic therapy of "early" squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree

Hubert van den Bergh, Christian Depeursinge, Georges Wagnières, André Châtelain

The efficacy of photodynamic therapy (PDT) alone was evaluated on 41 ‘early’ squamous cell carcinomas of the pharynx (10), oesophagus (15) and tracheo-bronchial tree (16). All lesions but two were synchronous second primaries in ENT-patients suffering from ...

1990