Publications related to Catecholaminergic polymorphic ventricular tachycardia

Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...

EPFL2023

Atomic-Level and Surface Structure of Calcium Silicate Hydrate Nanofoils

Karen Scrivener, Paul Bowen, Aslam Kunhi Mohamed, Ziga Casar

Deciphering the calcium silicate hydrate (C-S-H) surface is crucial for unraveling the mechanisms of cement hydration and property development. Experimental observations of C-S-H in cement systems suggest a surface termination which is fundamentally differ ...

AMER CHEMICAL SOC2023

Hardware-oriented pruning and quantization of Deep Learning models to detect life-threatening arrhythmias

Alexandre Schmid, Lizeth Gonzalez Carabarin

Wearable solutions based on Deep Learning (DL) for real-time ECG monitoring are a promising alternative to detect life-threatening arrhythmias. However, DL models suffer of a large memory footprint, which hampers their adoption in portable technologies. Th ...

IEEE2021

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

Silvestro Micera

Continuous and reliable cardiac function monitoring could improve medication adherence in patients at risk of heart failure. This work presents an innovative implantable Fiber Bragg Grating-based soft sensor designed to sense mechanical cardiac activity. T ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Johan Auwerx, Umberto De Marchi, Tanes Imamura de Lima

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

Nature Portfolio2021

Ventricular response regularity in atrial fibrillation and its relationship to successful catheter ablation

Jean-Marc Vesin, Adrian Luca, Etienne Pruvot

Atrial rate is known to modulate ventricular response during atrial fibrillation (AF). The resulting pulse irregularity translates into widely varying inter-beat intervals (IBIs) extracted from recorded surface electrocardiogram (ECG) activity. In AF, the ...

IEEE2020

Outer loop and isthmus in ventricular tachycardia circuits: Characteristics and implications

Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani

BACKGROUND The isthmus of ventricular tachycardia (VT) circuits has been extensively characterized. Few data exist regarding the contribution of the outer loop (OL) to the VT circuit. OBJECTIVE The purpose of this study was to characterize the electrophysi ...

2020

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Georgios Rovas, Bram Trachet, Vasiliki Bikia, Stamatia Zoi Pagoulatou, Mauro Ferraro

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Can one detect atrial fibrillation using a wrist-type photoplethysmographic device?

Jean-Marc Vesin, Célestin Leupi, Mathieu Lemay, Sibylle Fallet, Etienne Pruvot, Philippe Renevey

This study aims at evaluating the potential of a wrist-type photoplethysmographic (PPG) device to discriminate between atrial fibrillation (AF) and other types of rhythm. Data from 17 patients undergoing catheter ablation of various arrhythmias were proces ...

SPRINGER HEIDELBERG2019

Mapping Biological Current Densities With Ultrafast Acoustoelectric Imaging: Application to the Beating Rat Heart

Pierre-Marc Jean Marie Dansette

Ultrafast acoustoelectric imaging (UAI) is a novel method for the mapping of biological current densities, which may improve the diagnosis and monitoring of cardiac activation diseases such as arrhythmias. This paper evaluates the feasibility of performing ...

Institute of Electrical and Electronics Engineers2019

Cortical reactive balance responses to unexpected slippages while walking: a pilot study

Silvestro Micera, Daniela De Venuto

Understanding how the human brain cortex behaves when the dynamical balance is unexpectedly challenged can be useful to enable fall prevention strategies during daily activities. In this respect, we designed and tested a novel methodological approach to ea ...

IEEE2019

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Alfio Quarteroni, Luca Dede', Simone Rossi, Luca Barbarotta

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Non-invasive hemodynamic monitoring by electrical impedance tomography

Martin Proença

The monitoring of central hemodynamic parameters such as cardiac output (CO) and pulmonary artery pressure (PAP) is of paramount clinical importance to assess the health status of the cardiovascular system. However, their measurement requires the insertion ...

EPFL2017

False arrhythmia alarms reduction in the intensive care unit: a multimodal approach

Jean-Marc Vesin, Sasan Yazdani, Sibylle Fallet

The purpose of this study was to develop algorithms to lower the incidence of false arrhythmia alarms in the ICU using information from independent sources, namely electrocardiogram (ECG), arterial blood pressure (ABP) and photoplethysmogram (PPG). Our app ...

Institute of Physics2016

A Multimodal Approach to Reduce False Arrhythmia Alarms in the Intensive Care Unit

Jean-Marc Vesin, Sasan Yazdani, Sibylle Fallet

As part of the 2015 PhysioNet/CinC Challenge, this work aims at lowering the number of false alarms, which are a persistent concern in the intensive care unit. The multimodal database consists of 1250 life-threatening alarm recordings, each categorized as ...

2015

An effective algorithm for the generation of patient-specific Purkinje networks in computational electrocardiology

Fabio Nobile, Christian Vergara, Elena Faggiano

The Purkinje network is responsible for the fast and coordinated distribution of the electrical impulse in the ventricle that triggers its contraction. Therefore, it is necessary to model its presence to obtain an accurate patient-specific model of the ven ...

Elsevier2015

Influence of heart motion on cardiac output estimation by means of electrical impedance tomography: a case study

Jean-Philippe Thiran, Mathieu Lemay, Fabian Braun, Martin Proença, Michaël Rapin

Electrical impedance tomography (EIT) is a non-invasive imaging technique that can measure cardiac-related intra-thoracic impedance changes. EIT-based cardiac output estimation relies on the assumption that the amplitude of the impedance change in the vent ...

Iop Publishing Ltd2015

Risk Assessment of Atrial Fibrillation: a Failure Prediction Approach

David Atienza Alonso, Giovanni Ansaloni, Ruben Braojos Lopez, Daniel Camilo Rojas Quirós

We present a methodology for identifying patients who have experienced Paroxysmal Atrial Fibrillation (PAF) among a given subject population. Our work is intended as an initial step towards the design of an unobtrusive portable system for concurrent detect ...

Institute of Electrical and Electronics Engineers2014

Early Classification of Pathological Heartbeats on Wireless Body Sensor Nodes

David Atienza Alonso, Giovanni Ansaloni, Ruben Braojos Lopez, Ivan Beretta

Smart Wireless Body Sensor Nodes (WBSNs) are a novel class of unobtrusive, battery-powered devices allowing the continuous monitoring and real-time interpretation of a subject's bio-signals, such as the electrocardiogram (ECG). These low-power platforms, w ...

MDPI2014

Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Toni Mikael Lassila, Simone Rossi, Adélia Sequeira

The complex phenomena underlying mechanical contraction of cardiac cells and their influence in the dynamics of ventricular contraction are extremely important in understanding the overall function of the heart. In this paper we generalize previous contrib ...

Elsevier2014