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Related publications (26)

Ubiquitous aluminium contamination in water and amyloid hybrid membranes as a sustainable possible solution

Francesco Stellacci, Raffaele Mezzenga, Malvina Julia Ida Pauchard

We develop a membrane technology based on amyloid fibrils to remove aluminium from water and minimize its exposure to humans. We study aluminium adsorption by amyloid fibrils by evaluating the binding isotherms, the thermodynamics and the effects of differ ...

Royal Society of Chemistry2019

Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones

Paolo De Los Rios, Alessandro Barducci, Alberto Stefano Sassi, Salvatore Assenza

Hsp70 molecular chaperones are abundant ATP-dependent nanomachines that actively reshape non-native, misfolded proteins and assist a wide variety of essential cellular processes. Here, we combine complementary theoretical approaches to elucidate the struct ...

2019

On the definition of an effective stress for shales

Lyesse Laloui, Alessio Ferrari, Angelica Tuttolomondo

Energy-related engineering applications involving shales pose ever-increasing challenges for the constitutive modelling of these geomaterials. The present work proposes a new definition of effective stress developed by using a thermodynamic approach associ ...

2019

Non equilibrium thermodynamics of protein organization

Alberto Stefano Sassi

Three quarters of the thesis will be devoted to the discussion of non equilibrium systems. We show how certain biological systems cannot be described by standard thermodynamics. The reason is that the energy consumption due to the hydrolysis of ATP imposes ...

EPFL2018

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

Paolo De Los Rios, Alessandro Barducci, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Alberto Stefano Sassi

During and after protein translation, molecular chaperones require ATP hydrolysis to favor the native folding of their substrates and, under stress, to avoid aggregation and revert misfolding. Why do some chaperones need ATP, and what are the consequences ...

2018

High-pressure NMR spectroscopic and calorimetric studies on formic acid dehydrogenation and carbon dioxide hydrogenation

Cornel Fink

Our current energy production is convenient and simple, but it is not sustainable. The negative impacts on our environment are omnipresent in the form of smog, extinction of species, and global warming. A major challenge of our generation is the transition ...

EPFL2018

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