Publications related to Detrusor muscle

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Decoding bladder state from pudendal intraneural signals in pigs

Silvestro Micera, Stéphanie Lacour, Leonardo Pollina, Ivo Strauss, Valentina Marie Paggi

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

2023

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

Kunal Sharma

Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...

EPFL2021

Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent reversible neurological disorder characterized by impaired locomotion, cognition and urinary control with ventriculomegaly. Symptoms can be relieved with cerebrospinal fluid drainage, which mak ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Impedance pumping as a non-invasive treatment for underactive bladder? An ex-vivo proof-of-concept-study in porcine bladders

Yves Perriard, Yoan René Cyrille Civet, Francesco Clavica

In patients suffering from underactive bladder (UAB), the contraction of the detrusor muscle has insufficient strength or duration to ensure efficient bladder emptying. Although catheterisation is currently the most effective method to empty the bladder, i ...

2019

Development of a biologically inspired in-vitro platform for long-term assessment of commercial and innovative ureteral stents

Yves Perriard, Yoan René Cyrille Civet, Francesco Clavica

Ureteral stents are small flexible tubes which are clinically used to restore the urine drainage in presence of obstructions of the ureteral lumen such as tumours, kidney/ureteral stones. The lifetime risk of developing urinary stones is about 20% in men a ...

2019

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat ...

ELSEVIER SCI LTD2018

Neuromodulation in the restoration of function after spinal cord injury

Nicholas David James

Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chroni ...

2018

A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat

Stéphanie Lacour, Ivan Rusev Minev, Katherine Marie Musick

A severe complication of spinal cord injury is loss of bladder function (neurogenic bladder), which is characterized by loss of bladder sensation and voluntary control of micturition (urination), and spontaneous hyperreflexive voiding against a closed sphi ...

American Association for the Advancement of Science2013

Culture and Characterization of Human and Porcine Urothelial Progenitor Cells

Hans Mattias Larsson

An estimated 400 million people worldwide suffer from bladder diseases. However, little is known at the cellular level as to what causes or initiates many of these diseases. Therefore, this thesis has focused on understanding one cell type within the bladd ...

EPFL2012

Hydrogels for Urinary Tract Tissue Engineering

Lionel Ambroise Micol

Several urinary tract disorders, such as hypospadias or bladder cancer, require reconstructive surgery to preserve the patient's quality of life and at times even save their life. The current available surgical treatments, involving grafts from other tissu ...

EPFL2011

Compressed collagen gel: a novel scaffold for human bladder cells

Florian Maria Wurm, Jeffrey Alan Hubbell, Peter Frey

Collagen is highly conserved across species and has been used extensively for tissue regeneration; however, its mechanical properties are limited. A recent advance using plastic compression of collagen gels to achieve much higher concentrations significant ...

Wiley-Blackwell2010

Endoscopic Fluorescence Imaging : Spectral Optimization and in vivo Characterization of Positive Sites by Magnifying Vascular Imaging

Blaise Lovisa

Since several decades, the physicians are able to access hollow organs with endoscopic methods, which serve both as diagnostic and surgical means in a wide range of disciplines of the modern medicine (e.g. urology, pneumology, gastroenterology). Unfortunat ...

EPFL2010

High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix (R). Although the sensi ...

SPIE Society of Photo-optical Instrumentation Engineers2010

Tissue engineering of the bladder : exploiting a 3D hydrogel for modulation of the smooth muscle cell phenotype

Catharina Adelöw

Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...

EPFL2009

Fluorescence cystoscopy: Perspective in clinical practice and research

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Many studies confirm the clinical interest of photodynamic diagnostics (PDD) in non-muscle invasive bladder cancer management. PDD or fluorescence cystoscopy is not only of great value in occult urothelial cancer detection, but may have a positive impact o ...

Springer Verlag2008

Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolevulinic acid: Preliminary results

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: In bladder cancer, conventional white light endoscopic examination of the bladder does not provide adequate information about the presence of "flat" urothelial lesions such as carcinoma in situ. In the present investigation, we ex ...

1997

Clinical value of fluorescence cystoscopy in the detection of superficial transitional cell carcinomas of the bladder

Hubert van den Bergh, Georges Wagnières

The prognosis of superficial bladder cancer in terms of local recurrence and transformation into invasive cancer is related to the multiplicity of tumor sites and the concomitant presence of "flat" tumours, such as dysplasia and carcinoma in situ. This stu ...

1997