Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antag ...
High-resolution Doppler is a popular tool for evaluating cardiovascular physiology in mutant mice, though its 1-D nature and spectral broadening processes complicate interpretation of the measurement. Hence, it is crucial for pre-clinical researchers to kn ...
The ApoE(-/-) mouse is a common small animal model to study atherosclerosis, an inflammatory disease of the large and medium sized arteries such as the carotid artery. It is generally accepted that the wall shear stress, induced by the blood flow, plays a ...
Background: Low and oscillatory wall shear stresses (WSS) near aortic bifurcations have been linked to the onset of atherosclerosis. In previous work, we calculated detailed WSS patterns in the carotid bifurcation of mice using a Fluid-structure interactio ...
This thesis addresses the development and implementation of efficient and parallel algorithms for the numerical simulation of Fluid-Structure Interaction (FSI) problems in hemodynamics. Indeed, hemodynamic conditions in large arteries are significantly aff ...
Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...
Experimental data from animal models and clinical studies support connections between the haemostasis and inflammation in atherogenesis. These interfaces among inflammation and thrombogenesis have been suggested as targets for pharmacological intervention ...
BackgroundCoronary atherothrombosis due to atherosclerotic plaque rupture or erosion is frequently associated with acute coronary syndromes (ACS). Significant efforts have been made to elucidate the pathophysiological mechanisms underlying acute coronary e ...
Recently, an apolipoprotein E-deficient (ApoE(-/-)) mouse model with a mutation (C1039G+/-) in the fibrillin-1 (Fbn1) gene (ApoE(-/-)Fbn1(C1039G+/-) mouse model) was developed showing vulnerable atherosclerotic plaques, prone to rupture, in contrast to the ...
