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Related publications (29)

Time-resolved photoelectron spectroscopy of adenine and adenosine in aqueous solution

Time-resolved photoelectron spectroscopy is applied to study the excited state dynamics of the DNA base adenine and its ribonucleoside adenosine in aqueous solution for pump and probe photon energies in the range between 4.66 eV and 5.21 eV. We follow the ...

Royal Soc Chemistry2013

Synthesis and Properties of Highly-Charged Cationic Polyelectrolytes

Hamideh Ahmadloo

Polyelectrolytes (PEL) and PEL complexes formed by electrostatic interaction are recognized as compounds with a remarkable potential for a wide field of applications. However, comprehensive knowledge about electrostatic and structural influences on the pol ...

EPFL2013

Thermodynamics of Writhe in DNA Minicircles from Molecular Dynamics Simulations

Jonathan Mitchell

DNA supercoiling plays a role in genetic control by imposing torsional stress. This can induce writhe, which changes the global shape of the DNA. We have used atomistic molecular dynamics simulations to partition the free energy changes driving the writhin ...

Amer Physical Soc2013

Controlling a Single DNA Molecule in an Electric Field by Means of In Situ Atomic Force Microscopy

Giovanni Dietler, Jae Sun Jeong

DNA is the bio-polymer containing the genetic information needed for the development and functioning for all living organisms. It has a polymeric structure consisting of units called nucleotides, each consisting of a non-polar, hydrophobic interior (the ba ...

Electrochemical Society2012

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

Ursula Röthlisberger, Hilal Lashuel, Florence Pojer, Bruno Claude Daniel Fauvet, Michele Cascella, Marilisa Neri, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk, Min Kyu Cho, Amer Ashrafi

Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically trimer f ...

Public Library of Science2012

Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics

Christian Hartinger, Alexey Nazarov, Andrew Douglas Phillips

Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear rut ...

2011

Binding of Organometallic Ruthenium(II) Anticancer Compounds to Nucleobases: A Computational Study

Ursula Röthlisberger, Ivano Tavernelli, Christian Gossens

The reaction of the anticancer compound (eta(6)-benzene)Ru(en)(OH2) (1) toward the nucleobases guanine, adenine, and cytosine is studied computationally using DFT/BP86 calculations. The aqua leaving group of such compounds is known to undergo ligand ...

2009

Synthesis and characterization of novel polyelectrolytes based on double-charged cationic monomers

Ricardo Losada Mateo

Bis-1,3(N,N,N-trimethylammonium)-2-propylmethacrylate dichloride (di-M) and bis-1,3(N,N,N-trimethylammonium)-2-propylacrylate dichloride (di-A), two new double-charged monomers, were the subject of the research reported in this thesis. These monomers provi ...

EPFL2009

Conformational analysis of nucleic acids revisited: Curves

John Maddocks, Daiva Petkeviciute

We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algori ...

Oxford University Press2009

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