Publications related to Osteogenesis imperfecta

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

An individual polygenic risk score was associated with osteoporosis in people living with HIV. The genetic effect was robust, as it persisted after multivariable adjustment for established traditional and HIV-related osteoporosis risk factors, including te ...

OXFORD UNIV PRESS INC2023

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari, Tatiana Kochetkova

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Potential blindness in children of patients with hereditary bone disease

Mono- and bi-allelic mutations in the low-density lipoprotein receptor related protein 5 (LRP5) may cause osteopetrosis, autosomal dominant and recessive exudative vitreoretinopathy, juvenile osteoporosis, or persistent hyperplastic primary vitreous (PHPV) ...

Springer London Ltd2016

Impact of individual anatomy on the benefit of cup medialisation in total hip arthroplasty

Alexandre Terrier, Hannes Andreas Rüdiger, Valérie Parvex

Introduction: In total hip arthroplasty, cup medialisation with compensatory increase of femoral offset has been proposed to increase the moment arms of abductor muscles. However, this technique is associated with a loss of acetabular bone stock. Previous ...

Wichtig Publishing2016

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

A Ball-Screw Driven Motorized Hip Orthosis

Hannes Bleuler, Reymond Clavel, Mohamed Bouri, Jeremy Olivier, Amalric Louis Ortlieb

In this paper we present a motorized hip orthosis to assist elderly people while walking, stair climbing and during the sit-to-stand transitions. The design is based on biomechanics considerations. Ranges of motion, velocities and torques of the hip joint ...

2014

Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis

John Botsis, Joël Cugnoni, Marco Piccinini

Implanted rat bones play a key role in studies involving fracture healing, bone diseases or drugs delivery among other themes. In most of these studies the implants integration also depends on the animal daily activity and musculoskeletal loads, which affe ...

Elsevier2014

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Mario Michael Zaiss, Zhen Chen

Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism o ...

Amer Assoc Advancement Science2014

Development of an Assistive Motorized Hip Orthosis

Hannes Bleuler, Reymond Clavel, Mohamed Bouri, Jeremy Olivier, Amalric Louis Ortlieb

With the increase of life expectancy, a higher number of elderly need assistance to maintain their mobility and their independance. The hip joint is crucial for walking and is problematic for a large number of aged people. In this paper we present a novel ...

2013

Combined effects of zoledronate and mechanical stimulation on bone adaptation in an axially loaded mouse tibia

Dominique Pioletti, Vincent Stadelmann

Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...

Elsevier2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti, Lee Ann Laurent-Applegate

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Dominique Pioletti, Alexandre Terrier, Pierre-Etienne Bourban, Alireza Roshan Ghias

In clinical situations, bone defects are often located at load bearing sites. Tissue engineering scaffolds are future bone substitutes and hence they will be subjected to mechanical stimulation. The goal of this study was to test if cyclic loading can be u ...

European Cells & Materials Ltd2010

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Dominique André Rothenfluh

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Targeted mechanical properties for optimal fluid motion inside artificial bone substitutes

Dominique Pioletti, Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Luc Blecha

The goal of this study was to develop a method that identifies optimal elastic modulus, Poisson’s ratio, porosity and permeability values for mechanically stressed bone substitute. It was hypothesized that porous bone substitute that favors the transport o ...

2009

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Embedded Shape-Memory Alloy Wires for Improved Performance of Self-Healing Polymers

Véronique Michaud, Eva Kirkby

We report the first measurements of self-healing polymers with embedded shape memory alloy (SMA) wires. The addition of SMA wires shows improvements of healed peak fracture loads by up to a factor of 1.6, approaching the performance of the virgin material. ...

2008