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Related publications (26)

Be squared: expanding the horizon of squaric acid-mediated conjugations

Harm-Anton Klok, Frederik Roman Wurm

Squaric acid diesters can be applied as reagents to couple two amino-functional compounds. Consecutive coupling of two amines allows the synthesis of asymmetric squaric acid bisamides with either low molecular weight compounds but also biomolecules or poly ...

Royal Society of Chemistry2013

Uncommon 1,2-Migration of a Nitro Group Within a beta-Nitrostyryl Moiety: Synthetic Scope and Mechanistic Details

Marco Stenta

The unusual migration of a nitro group from the - to the -position of a -aryl--nitroethenyl moiety, following a nitrocyclopropane to isoxazoline N-oxide isomerization, has been studied from a mechanistic and synthetic points of view. As a result, two serie ...

Wiley-V C H Verlag Gmbh2013

Spatio-Temporal Presence of Micropollutants and their Metabolites in Lake Geneva and Susceptibility to Direct and Indirect Photodegradation Processes

Florence Bonvin

Invisible to the human eye, yet ubiquitous... The occurrence and the potential adverse effects of micropollutants in the environment are uncontested. Due to incomplete removal by conventional wastewater treatment technologies, the aquatic environment is co ...

EPFL2013

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Christian Hartinger, Wee Han Ang, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Albert Ruggi, Frédéric Schmitt, Julie Risse

Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite1,2-O-isopropylidene-alpha-D-glucofuranoside, were prepared in order to evaluate their ...

2012

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

Hilal Lashuel, Andrea Pfeifer, Annalisa Ansaloni, Mohammad Asad Jan Qureshi, Andreas Muhs, Magdalena Zweckstetter, Paolo Paganetti

Increasing evidence implicates Aβ peptides self-assembly and fibril formation as crucial events in the pathogenesis of Alzheimer disease. Thus, inhibiting Aβ aggregation, among others, has emerged as a potential therapeutic intervention for this disorder. ...

Amer Soc Biochemistry Molecular Biology Inc2012

DprE1 as a Drug Target from Mycobacterium Tuberculosis

Claudia Trefzer

Benzothiazinones (BTZs) form a new class of potent antimycobacterial agents with a minimal inhibitory concentration of 1 ng/mL against Mycobacterium tuberculosis. Although the target of BTZs has been identified as decaprenylphosphoryl--D-ribose 2- oxidase ...

EPFL2012

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