Lectures related to Drug | EPFL Graph Search

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Drug Targets: Adrenergic Signaling

Explores drug targets and adrenergic signaling, covering receptors, enzymes, and transporter proteins.

Pharmacological Targets and Interventions

Explores targets for drug action and the design of specific inhibitors.

Machine Learning Approaches to Human Disease

Explores the impact of machine learning in understanding human diseases, focusing on historical significance, natural products discovery, and challenges in designer drugs.

Drug Targets: ligand-gated ion channels and kinase-linked receptors

Explores drug targets in ligand-gated ion channels and kinase-linked receptors, focusing on GABAA receptors, benzodiazepines, and insulin therapy.

Proteome Mapping & Electrophile Responsivity

Explores proteome mapping, electrophile responsivity, precision medicine, and spatial omics technologies in drug target identification.

Drug Targets: Ligand-Gated Ion Channels and Kinase-Linked Receptors

Explores drug targets like ligand-gated ion channels and kinase-linked receptors, discussing mechanisms of action, clinical uses, and insulin's physiological context.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.

Therapeutic Monitoring: Tato for Jane Doe

Discusses therapeutic monitoring principles using Bayes' theorem for personalized treatment.

Pharmacodynamics: Ligand-Receptor Interactions and Drug Effects

Explores ligand-receptor interactions, drug effects, modulation mechanisms, and factors influencing drug responses.

Pharmacodynamics: Ligand-Receptor Binding and Drug Effects

Explores ligand-receptor binding, drug effects, efficacy, potency, and biased agonism in pharmacodynamics.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

Enzyme Inhibition Mechanisms

Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.

Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Machine Learning-Guided Treatment Discovery

Explores personalized medicine, machine learning for treatment prediction, and challenges in traditional algorithms.

Neurotransmitters: Receptors and Effects

Explores major neurotransmitters, their effects, drug therapy, and receptor mechanisms in brain function.

Pharmacokinetics Modeling: Zero and First-Order Kinetics

Explores pharmacokinetics modeling, covering zero and first-order kinetics, drug distribution, and key parameters for drug elimination.

Pharmacokinetic & Pharmacodynamic Studies

Discusses the importance of assessing PK/PD relationships in drug development and the use of multiple PD biomarkers.