Publications related to Movement disorder

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

SOC NEUROSCIENCE2023

Modeling spinal locomotor circuits for movements in developing zebrafish

Yann Roussel

Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...

eLIFE SCIENCES PUBL LTD2021

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

Lena Carcreff

Like 17 million people worldwide, an individual with cerebral palsy (CP) does not have the opportunity to walk harmoniously in society due to long-life impairments in movement and posture. The natural course of CP can be modulated by treatments and therapi ...

EPFL2020

Spatio-temporal structure of single neuron subthalamic activity identifies DBS target for anesthetized Tourette syndrome patients

Silvestro Micera, Matteo Vissani

Objective. Deep brain stimulation (DBS) of basal ganglia effectively tackles motor symptoms of movement disorders such as Tourette syndrome (TS). The precise location of target stimulation site determines the range of clinical outcome in DBS patients, and ...

IOP PUBLISHING LTD2019

e-Glass: A Wearable System for Real-Time Detection of Epileptic Seizures

David Atienza Alonso, Amir Aminifar, Dionisije Sopic

Today, epilepsy is one of the most common chronic diseases affecting more than 65 million people worldwide and is ranked number four after migraine, Alzheimer’s disease, and stroke. Despite the recent advances in anti-epileptic drugs, one-third of the epil ...

2018

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Silvestro Micera, Marco Bonizzato, Grégoire Courtine, Polina Shkorbatova, Natalia Pavlova, Galyna Pidpruzhnykova

The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...

Nature Publishing Group2018

Decoding of Self-paced Lower-Limb Movement Intention: A Case Study on the Influence Factors

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Dong Liu

Brain-machine interfaces (BMIs) have been applied as new rehabilitation tools for motor disabled individuals. Active involvement of cerebral activity has been shown to enhance neuroplasticity and thus to restore mobility. Various studies have focused on th ...

Frontiers Research Foundation2017

Motor imagery in spinal cord injured people is modulated by somatotopic coding, perspective taking, and post-lesional chronic pain

Polona Pozeg, Michele Scandola

Motor imagery (MI) allows one to mentally represent an action without necessarily performing it. Importantly, however, MI is profoundly influenced by the ability to actually execute actions, as demonstrated by the impairment of this ability as a consequenc ...

Wiley2017

Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition

Carl Petersen

The basal forebrain (BF) houses major ascending projections to the entire neocortex that have long been implicated in arousal, learning, and attention. The disruption of the BF has been linked with major neurological disorders, such as coma and Alzheimer's ...

Soc Neuroscience2015

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Modular organization of reaching and grasping movements investigated using EEG microstates

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Robert Leeb, Elvira Pirondini, Martina Coscia, Jesús Minguillón Campos

How movements are generated and controlled by the central nervous system (CNS) is still not well understood. In this work, we tested the hypothesis of a modular organization of the brain activity during the execution of voluntary movements. In particular, ...

IEEE2014

An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Elias Georges Gebara

Stimulation of resident cells by NF-kappa B activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system (CNS). This disease-mediated NF-kappa B activation could be used to drive transgene expression se ...

Public Library Science2013

A subject-specific software solution for the modeling and the visualization of muscles deformations

Daniel Thalmann, Ronan Boulic, Anders Sandholm, Xavier Maurice

Today, to create and to simulate a virtual anatomical version of a subject is useful in the decision process of surgical treatments. The muscular activity is one of the factors which can contribute to abnormal movements such as in spasticity or static cont ...

Springer-Verlag2009

Bio-electromagnetic model of deep brain stimulation

Grégoire Walckiers

Functional stimulation is one of the most fascinating applications of bioelectromagnetism. It deals with the stimulation of excitable biological tissues by electromagnetic fields. One of its most impressive medical applications is the subthalamic nucleus d ...

EPFL2009

Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system

Kamiar Aminian, Arash Salarian

An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the fore ...

2007

Ambulatory monitoring of motor functions in patients with Parkinson's disease using kinematic sensors

Arash Salarian

Parkinson's disease (PD) is the second most common neurodegenerative disease in the general population. Cardinal symptoms of Parkinson's disease are resting tremor, rigidity, akinesia and bradykinesia and in advanced stages, gait impairments, postural inst ...

EPFL2006

A Cross Validation Study of Deep Brain Stimulation Targeting: From Experts to Atlas-Based, Segmentation-Based and Automatic Registration Algorithms

Jean-Philippe Thiran, Meritxell Bach Cuadra, Olivier Cuisenaire, Reto Meuli, Francisco Javier Sanchez Castro

Validation of image registration algorithms is a difficult task and open-ended problem, usually application-dependent. In this paper we focus on deep brain stimulation (DBS) targeting for the treatment of movement disorders like Parkinson's disease and ess ...

Institute of Electrical and Electronics Engineers2006

Huntington's disease modeling and treatment : from primary neuronal cultures to rodents

Diana Zala

Huntington's disease (HD) is a mid-life-onset neurodegenerative disorder characterized by involuntary movements, personality changes and dementia. It progresses to death within 10-20 years after onset. There is currently no cure to treat this fatal disease ...

EPFL2005