CH-335: Asymmetric synthesis and retrosynthesis

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Lectures in this course (39)

Rétrosynthèse: Exercices

Covers exercises on retrosynthesis in organic chemistry.

Asymmetric Synthesis: Myers Auxiliary and Seebach Method

Explores asymmetric synthesis with Myers auxiliary, Seebach method, and Zimmermann-Traxler model for challenging stereocontrol.

Aldolization: Zimmermann-Traxler vs Evans Auxiliary

Compares Zimmermann-Traxler with Evans Auxiliary in aldolization and introduces Imines/Enamines.

Retrosynthesis: Complex Fragments Synthesis Strategy

Explores the retrosynthesis strategy for complex fragments synthesis, using Leucascandrolide A as a case study.

Chemistry of Imines and Enamines

Explores the chemistry of imines and enamines, including amine condensation, ketone-iminium reduction, and the use of chiral auxiliaries.

Retrosynthesis Principles

Explores retrosynthesis principles, emphasizing high yields, selectivity, protecting groups, and selective reduction.

Protecting Groups in Organic Chemistry

Explores protecting groups in organic chemistry and the electronic nature of aromatic compounds.

Aromatic Compounds: Coupling Agents and Selectivity

Explores aromatic compounds, coupling agents, and selectivity in reactions.

Functional Groups in Organic Chemistry

Covers the concept of functional groups in organic chemistry and their reactivity.

V-Cross Couplings: Suzuki Stille Coupling

Covers the principles and mechanisms of V-cross couplings, focusing on Suzuki and Stille couplings.

Steric Factors in Organic Chemistry

Explores diastereotopic epochs, vi-disconnections, steric factors, and the chelete effect in organic chemistry, along with the protection of alcohols and types of ethers.

Alkyltion of Carbonyl Compounds

Covers the alkyltion of carbonyl compounds, regioselectivity, and general methodologies.

Bifunctionalized Compounds: Strategies and Selectivity

Explores the synthesis strategies and selectivity of bifunctionalized compounds in organic chemistry.

Strategies for Bifunctionalized Compounds

Discusses strategies for bifunctionalized compounds and the insertion of carbenes on alkenes.

Complex Molecules: Fragments and Synthesis

Covers the synthesis of complex molecules from fragments, focusing on the most sensitive functions.

Carbocycles: Synthesis and Reactivity

Covers the synthesis and reactivity of carbocycles, focusing on chiral alcohols and cross-coupling reactions.

Total Synthesis of Discodermolide

Covers the total synthesis of Discodermolide, a potent immunosuppressive and cytotoxic compound.

Total Synthesis of Discodermolide

Covers the total synthesis of Discodermolide, focusing on key steps.

Wittig Reaction: Stereoselective Synthesis

Explores the stereoselective synthesis with the Wittig reaction and its variants.

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