Course

CH-411: Cellular signalling

Lectures in this course (22)

Explores TRP ion channels' role in sensory perception of heat, cold, and pain, modulation by various stimuli, and involvement in nociception and mechanosensation.

Cellular Signalling: Introduction & Mechanisms

Covers cellular signalling, including long-distance communication, receptor mechanisms, and the impact of small numbers in biology.

Lipid Rafts and Ion Channels

Explores lipid rafts, cholesterol modulation of signaling, and nicotinic ion channels.

Receptor-Ligand Interaction

Explores receptor-ligand interactions, covering binding, dissociation, equilibrium, and quantification methods.

Ligand-gated Ion Channels: Mechanisms and Models

Explores experimental approaches and models of ligand-gated ion channels, including the effects of nicotine.

Receptor-Ligand Interaction: Quantification and Mechanisms

Explores methods to quantify receptor-ligand interactions, ligand-gated ion channels, and the Hill equation.

Protein Domains & Interactions

Explores protein interactions, domains, scaffolds, and signaling networks in cellular biology.

Nuclear Receptors: Signalling and Health Implications

Explores nuclear receptors, JAK-STAT pathway, growth factors, endocrine disruptors, and estrogen receptors.

Membrane Binding Domains: PIP Signaling Pathway

Explores the role of membrane binding domains in the PIP signaling pathway and the recognition of PIPx species by specific domains.

Protein Interactions & Membrane Binding

Explores protein interactions, membrane binding, scaffolds, effective molarity, and genome-wide approaches in studying protein interactions.

Protein Lipidation: Membrane Localization and Signalling

Covers protein lipidation, membrane localization, major lipid classes, signaling modulation, and lipid rafts in biological membranes.

G Protein-Coupled Receptors: Signalling Diversity

Explores G protein-coupled receptors' signalling diversity, covering structure, activation, bias effects, and internalisation.

Protein Lipidation: Membrane Organization

Explores protein lipidation, membrane localisation, lipid modification impact on signalling, and dynamic lipidation processes.

Ligand-gated Ion Channels

Explores ligand-gated ion channels, focusing on nicotinic acetylcholine receptors, ion selectivities, and drug targeting.

G Protein-Coupled Receptors: Signalling Diversity and Complexity

Explores the diversity and complexity of G protein-coupled receptors, focusing on their signalling pathways, ligand effects, and cellular activity.

TRP Channels: Structure and Function

Explores the structure and function of TRP channels in temperature and pain perception, covering topics such as activation by capsaicin and modulation of channel currents.

TRP Channels: Sensory Perception

Explores TRP channels' role in sensory perception, focusing on their activation by various stimuli and their implications in disease pathogenesis.

Receptor Tyrosine Kinases: Signalling and Regulation

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Nicotinic Receptors: Structure and Function

Explores the structure and function of nicotinic receptors, focusing on Cys-loop receptors, ion conductance, and the effects of nicotine.

G Protein-Coupled Receptors: Structure and Signalling

Explores the structure, signalling, and drug targeting of G protein-coupled receptors, emphasizing their importance in pharmaceutical research.