Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.
Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.
Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.
Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.
Delves into identifying drug targets, ensuring efficacy, and maintaining safety in medical chemistry, covering genetic tests, chirality, stereochemistry, drug resistance, and drug-likeness rules.