Lectures related to Designing Targeted Protein Degraders

Enzyme Inhibition Mechanisms

Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

Frontiers in Chemical Biology

Explores the druggable proteome, PROTACS strategy, ubiquitin attachment, and drug development paradigms.

Protein Function Regulation: Degradation Mechanisms

Covers the mechanisms of protein degradation, including the roles of the proteasome and autophagy in regulating protein function.

Protein Induced Degradation: Druggability Strategy

Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.

PROTACs: Catalytic Protein Knockdown Strategy

Explores PROTACs, a catalytic protein knockdown strategy with potential in tumor treatment and drug development.

Protein Modifications: Ubiquitination and Acylation

Explores protein modifications through ubiquitination, acylation, and Ras acylation importance.

Ubiquitination: Protein Degradation

Explores ubiquitination, protein degradation, and cellular regulation through ubiquitin tagging, covering various cellular processes and pathways.

Membrane Protein Quality Control at ER

Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.

DNA Replication: Sister Chromatids Cohesion

Explores DNA replication in eukaryotes and the cohesion of sister chromatids.

Molecular machines involved in mycobacterial protein quality control pathways

Explores molecular machines in mycobacterial protein quality control pathways, focusing on degradation, proteases, and pupylation-dependent degradation.

Regulation Mechanisms Overview

Covers phosphorylation, ubiquitinylation, methylation, and more in biological regulation.

Protein Maturation: Post-Translational Modifications

Covers the maturation of proteins and the role of post-translational modifications in their functionality and regulation.

Protein Quality Control of Membraneless Organelles

Explores protein quality control in membraneless organelles and its implications for diseases.

Bacterial AAA+ Protease: Activity Control and Toxic Deregulation

Explores the activity control and toxic deregulation of a bacterial AAA+ protease, focusing on the role of AAA+ machines in protein quality control.

The ClpXP Proteolytic Complex: Basic Principles to Drug Discovery

Explores the ClpXP proteolytic complex, its drug targeting potential, and antimicrobial applications through compound screening.