Lectures related to Altered Pathways in Cancer: Signaling Cascades and Mutations

Sustained Proliferation: Signaling Pathways and Cancer Genes

Covers sustaining proliferation in cancer cells, growth factors, receptor tyrosine kinases, signal transduction, viral oncogenes, and therapeutic opportunities.

Cell Signalling: Receptors and Pathways

Explores cell signalling mechanisms, including receptors, pathways, and signal transduction for gene regulation and cellular responses.

Sustained Proliferation: RTK/PI3K/mTOR Pathway in Cancer

Explores the RTK/PI3K/mTOR pathway in cancer, inhibitors, completed trials, and effects of Akt/PKB on survival and proliferation.

Evading Growth Suppression: TGFB Signaling

Explores how cells evade growth suppression, focusing on TGFB signaling and the role of tumor suppressors like PTEN and p53.

Tyrosine Kinases & Ras Signaling

Explores tyrosine kinases, Ras activation, lipid signaling, cancer implications, and signal transduction in cells.

Altered Metabolism in Cancer: Warburg Effect and MYC Regulation

Explores altered cancer metabolism, MYC regulation, Rb and p53 pathways, AKT re-activation, and protein-protein interactions.

Mutations and Cancer: The Role of P53 and HPV

Covers mutations, the role of P53 in cancer, and HPV's impact on tumorigenesis.

Receptor Tyrosine Kinases: Signalling and Regulation

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Genetic Mutations: Causes and Effects

Explores genetic mutations, chromosomal abnormalities, DNA repair, and disease implications.

Melanocytes and Hair Color Regulation

Examines paracrine communication in melanocytes, CAMP influence on hair color, Mc4R mutations, and fur phenotypes.

Apoptosis: Regulation and Signaling

Explores apoptosis regulation, impact on tumors, survival signaling pathways, autophagy in cancer, and challenges in mTOR targeting.

Protein Phosphorylation: Mechanisms and Regulation

Explores protein phosphorylation, its structural effects, kinase activity, and its role in signaling and disease.

Cell Patterning and Signalling Pathways

Explores cell patterning, signalling pathways, and genetic mutations in biological development.

Cellular Communication: Signaling Pathways and Receptors

Delves into the importance of intercellular communication and the diverse signaling pathways involved in cellular responses.

Cancer Biology: p53 and DNA Repair

Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, tumor suppressor genes, metastasis, and genetic alterations driving tumorigenesis.

Cell Membrane Receptors: General Principles

Explains cell membrane receptors, signal transduction, and second messengers.

Genomic Alterations in Cancer

Explores genetic and epigenetic changes in cancer, including mutations, chromosomal alterations, and high-throughput measurement methods.

Molecules of Life: Understanding Translation and Protein Synthesis

Provides an overview of translation and protein synthesis, covering the genetic code, tRNA, and the steps involved in protein formation.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.