Lectures related to Drug Metabolism: Xenobiotics and Enzymes

Pharmacogenetics: Drug Response and Genetic Variability

Delves into pharmacogenetics, exploring genetic influences on drug response variability and metabolism.

Drug-Induced Liver Injury (DILI): Mechanisms and Mitigation

Delves into Drug-Induced Liver Injury (DILI) mechanisms, metabolism, and mitigation strategies in drug development.

Drug-Induced Liver Injury: Mitigation Strategies

Explores Drug-Induced Liver Injury mechanisms, mitigation strategies, and challenges in drug development.

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Pharmacodynamics: Ligand-Receptor Interactions and Drug Effects

Explores ligand-receptor interactions, drug effects, modulation mechanisms, and factors influencing drug responses.

Liver Detoxification: Bile Acids, Cholesterol, and Xenobiotics

Explores liver metabolism of bile acids, cholesterol, and xenobiotics, emphasizing detoxification processes and lipid transport.

Metabolism Integration: Gluconeogenesis and Glycolysis

Discusses the integration of metabolic pathways, focusing on gluconeogenesis and glycolysis, and their hormonal regulation in maintaining glucose homeostasis.

Selective Drug Targeting Mechanisms

Explores selective drug targeting mechanisms, resistance development, tuberculosis incidence, BCR-ABL mutations, tyrosine kinase inhibitors, drug toxicity, interactions, and toxicology studies.

Cellular Communication and Metabolism: Energy Transformation Principles

Discusses cellular communication, metabolism, energy transformation, and the role of enzymes in biochemical reactions.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Nuclear Receptors: Drug Targets

Explores nuclear receptors, their role in drug pharmacology, and physiological functions in adipose tissue and glucose homeostasis.

Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Pharmacokinetics: Drug Excretion and Transporters

Explores drug excretion pathways, renal function, and transporter roles.

Drug Targets: Nuclear Receptors

Explores drug targets, particularly nuclear receptors like PPARy and pregnane X receptor, and their impact on endocrine signaling and drug pharmacokinetics.

Metabolism and Hormones

Explores tissue-specific metabolism, hormone regulation, and enzyme cascades in glucose and lipid metabolism.

Interrogating SAR in Medical Chemistry

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Interrogating SAR: Medicinal Chemistry

Covers medicinal chemistry basics, high-throughput screening, lead discovery milestones, and compound selectivity in drug optimization.

Neurotransmitters: GABA and Glycine

Explores the classification and effects of GABA and Glycine neurotransmitters, including drug interactions.

Metabolism and Hormones

Explores metabolic processes in different tissues and the role of hormones.