Lecture

Protein-Ligand Interactions: Importance and Affinity

Related lectures (32)

Series explores computational protein design, covering challenges, applications, and importance in bioengineering and synthetic biology.

Enzymes: Basic Concepts and Kinetics

Explores enzymes' catalytic strategies, kinetics, and inhibition, emphasizing their role in accelerating biochemical reactions.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Protein Structure Determination: NMR Insights

Explores NMR spectroscopy for protein structure determination and introduces Cryo-EM as a complementary technique with recent advancements.

Protein Structure and Function: Folding and Degradation

Covers protein folding, maturation, degradation, and the implications of misfolding in neurodegenerative diseases.

Enzymology: Structure, Kinetics, and Inhibition

Covers enzyme structure, kinetics, inhibition, specificity, and practical applications in enzymology.

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.

Synchrotrons and X-ray Techniques

Explores synchrotrons, X-ray techniques, crystallography, enzyme structures, mutant engineering, and the future of macromolecular crystallography.

Enzyme Inhibitors: Drug Design and Tools

Explores enzyme inhibitors as drugs, drug design, and protein function, including activity-based protein profiling and genome probing tools.

Protein Interaction Fingerprinting with Geometric Deep Learning

Explores deciphering protein interaction fingerprints using geometric deep learning and the challenges in computational protein-protein interaction design.

Proteins and Allostery

Explores proteins' structure, function, cooperativity, and allostery, including action at a distance and protein evolution.

Inhibitor Design & Analysis

Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.