Lecture

Non-cell Autonomous Mechanisms: SOD1 Pathology

Related lectures (32)

SOD1 Pathology: Mechanisms and Implications

Explores SOD1 mutations in ALS, focusing on toxic gain of function, protein misfolding, and non-cell autonomous disease.

Glia Cells: Functions and Interactions

Explores the functions and interactions of glial cells in supporting neurons, myelination, and memory formation.

Glia: Structure and Function

Explores the structure and function of glial cells in the nervous system, including their roles in myelination, synaptic transmission, and memory formation.

Neural System Organization

Explores the organization and structure of the nervous system, including neurons, synapses, neurotransmitters, and brain functions.

Neural System Organization

Explores the organization of the nervous system, including neuron structure, synapses, neurotransmitters, and neural circuits.

DNAJB6: Chaperone Action & Nuclear Pore Assembly

Delves into DNAJB6's chaperone action, relevance to protein aggregation diseases, and interactions with various proteins.

Protein self-assembly and phase transitions

Delves into protein self-assembly, phase transitions, and aggregation mechanisms in diseases like Alzheimer's.

Protein Aggregation in Neurodegenerative Diseases

Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.

Foreign Body Reaction: Neural Interfaces

Explores the foreign body reaction to neural interfaces and the impact on implant performance.

Parkinson's Disease: Genetic Factors

Explores genetic factors in Parkinson's disease, focusing on a-synuclein, Parkin, and PINK1, and their impact on mitochondrial quality control.

Polyglutamine Protein Aggregation: Molecular Structure and Pathogenic Mechanisms

Explores beta-hairpins in polyglutamine protein aggregation, focusing on Huntington's disease and the molecular mechanisms behind toxic fibril formation.

Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions

Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.

Neurodevelopment: Early Days in Human Embryonic Development

Explores neurodevelopment in human embryos, from neurulation to adult neurogenesis, highlighting the influence of environmental factors and the connection to depression.

Protein Aggregation Kinetics and Drug Discovery

Explores protein aggregation kinetics, drug discovery, and targeting oligomers in misfolding diseases.

Protein Quality Control of Membraneless Organelles

Explores protein quality control in membraneless organelles and its implications for diseases.

Brain Mechanics: Structure and Properties

Explores the structure and properties of the brain's mechanics, including neural signals, electrodes, electrochemistry, and brain sizes.

Protein Aggregation Control

Explores protein aggregation control through optimal strategies, inhibitors, and spatial regulation using liquid compartments, shedding light on drug interventions and aggregate dynamics.

Protein Folding: Chaperone Solutions

Explores chaperones' role in guiding protein folding and preventing misfolding through the functional cycle of Hsp70 and the DnaK chaperone system.

RNA Metabolism: ALS Genetics

Delves into RNA metabolism in ALS genetics, focusing on key proteins, mutations, and implications in neurodegeneration.

Implant Foreign Body Reaction

Explores the foreign body reaction to implants, acute phase of insertion, perfusion impact, BBB rupture, repair processes, imaging, and cell staining.