Lectures related to Posttranslational Modifications: Phosphorylation and Protein Phosphatases

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.

Protein Phosphorylation: Mechanisms and Regulation

Explores protein phosphorylation, its structural effects, kinase activity, and its role in signaling and disease.

Receptor Tyrosine Kinases: Signalling and Regulation

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Tyrosine Kinases & Ras Signaling

Explores tyrosine kinases, Ras activation, lipid signaling, cancer implications, and signal transduction in cells.

Insulin Receptor Activation: Signaling Mechanisms

Explains insulin receptor activation and cytokine receptor signaling mechanisms in detail.

Cell Signalling: Receptors and Pathways

Explores cell signalling mechanisms, including receptors, pathways, and signal transduction for gene regulation and cellular responses.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

DNA Damage Checkpoint

Explores the DNA damage checkpoint, cell cycle regulation, repair mechanisms, and key proteins involved.

GPCRs: Molecular Endocrinology

Explores the structure and activation of 7TM receptors and the downstream effects of CAMP and protein kinase A.

Membrane Binding Domains: PIP Signaling Pathway

Explores the role of membrane binding domains in the PIP signaling pathway and the recognition of PIPx species by specific domains.

Cell Membrane Receptors: General Principles

Explains cell membrane receptors, signal transduction, and second messengers.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.

Glutamate Receptors: Functional Properties and Brain Mechanisms

Explores glutamate receptors, EPSPs, EPSCs, LTP, LTD, STDP, and dendritic spines.

Cellular Communication: Signaling Pathways and Receptors

Delves into the importance of intercellular communication and the diverse signaling pathways involved in cellular responses.

Proteomic Applications in Neuroscience: Targeting Cortical Neurons

Covers proteomic applications in neuroscience, focusing on targeted analysis of cortical neurons and their developmental interactions with striatal neurons.

Microbial Metabolic Diversity

Explores microbial metabolic diversity, enzyme catalysis, redox carriers, and Fe(III) reduction mechanisms.

Metabolic Signaling: Glycolysis and ATP Production

Explores glycolysis, ATP production, and metabolic signaling in cancer and drug discovery.

Electron Transport Chain: Proton Pumps and Coenzyme Q

Explores the Electron Transport Chain in mitochondria, focusing on proton pumps and Coenzyme Q.

Bacterial Signalling: Two-component Systems

Explores bacterial two-component signalling systems, gene regulation, chemotaxis, and flagellar rotation in E. coli.