Lectures related to Defining Your Synapse

Synaptic transmission: Structure and Mechanisms

Explores the structure and function of synapses, including neurotransmitter diversity and the role of AMPA and NMDA receptors.

Glutamate receptors: Structure and Function

Explores the structure, ion permeability, kinetics, and diversity of glutamate receptors, including AMPA and NMDA, as well as metabotropic receptors.

Compiling and testing modfiles

Covers the process of compiling and testing modfiles in NEURON with a focus on synapse dynamics.

Synaptic Transmission: Electrical vs. Chemical

Explores the differences between electrical and chemical synapses, synaptic plasticity, and receptor behavior.

Understanding Synaptic Transmission

Explores synaptic transmission, neurotransmitters, and neural plasticity principles.

Postsynaptic Potentials: Cellular Mechanisms

Explores cellular mechanisms of excitatory postsynaptic potentials, emphasizing synaptic summation for action potential threshold.

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Glutamate Receptors: Functional Properties and Brain Mechanisms

Explores glutamate receptors, EPSPs, EPSCs, LTP, LTD, STDP, and dendritic spines.

Synapses: Neuronal Dynamics

Explores the role of synapses in computational neuroscience and the models of excitatory and inhibitory synapses.

Neurotransmitters: Receptors and Effects

Explores major neurotransmitters, their effects, drug therapy, and receptor mechanisms in brain function.

Testing your synapse model in a neuron

Explores testing a synapse model in a neuron using NEURON software.

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Neurotransmitter Glutamate: Receptor Dynamics and Pharmacodynamics

Explores neurotransmitter dynamics, receptor interactions, and pharmacological concepts in CNS synapses.

Synaptic plasticity: mechanisms and functions

Explores the cellular mechanisms of synaptic plasticity, including LTP, LTD, and STDP.

Synaptic Transmission: Electrical vs Chemical

Compares electrical and chemical synapses, emphasizing their properties and behavior, including the neuromuscular junction and synapses in the CNS.

Configuring your synapse to realistic biological ranges

Covers configuring synapses to realistic biological ranges and visualizing NMDA conductance dependencies.

GABAergic inhibition

Explores the cellular mechanisms of GABAergic inhibition in the brain and the role of GABA receptors.

Pharmacodynamics exercises

Covers the analysis of binding measurements and toxin kinetics in pharmacodynamics.

Neurological Disorders: Alzheimer's & Anxiety

Explores Alzheimer's disease, anxiety, pain, and the renin-angiotensin system, including the development of the first renin inhibitor for clinical treatment.

Understanding the Brain

Explores the significance of brain electrical activity and its implications for understanding ourselves and developing mathematical models.