Lectures related to DNAJB6: Chaperone Action & Nuclear Pore Assembly

Protein self-assembly and phase transitions

Delves into protein self-assembly, phase transitions, and aggregation mechanisms in diseases like Alzheimer's.

Protein Aggregation in Neurodegenerative Diseases

Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.

Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Protein Structure and Function: Folding and Degradation

Covers protein folding, maturation, degradation, and the implications of misfolding in neurodegenerative diseases.

Understanding Tau Pathologies

Explores Tau pathologies in Alzheimer's and related disorders, covering hyperphosphorylation, propagation, genetic associations, and therapeutic interventions.

Cellular Heat Shock Response: Rethinking the Significance

Delves into the cellular heat shock response, emphasizing the absence of a sensor mechanism and the restoration of misfolded protein aggregates.

Dynamic Prion Assemblies: Catalytic Exchange and Structural Diversity

Explores the dynamic nature of prion assemblies and the structural diversity observed during the replication process.

Polyglutamine Protein Aggregation: Molecular Structure and Pathogenic Mechanisms

Explores beta-hairpins in polyglutamine protein aggregation, focusing on Huntington's disease and the molecular mechanisms behind toxic fibril formation.

Protein Disaggregation by Hsp70 Chaperone System

Explores protein disaggregation by the Hsp70 chaperone system and the significance of aggregate modification for protein refolding.

Protein-Repair Machineries: Evolution and Function

Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.

SOD1 Pathology: Mechanisms and Implications

Explores SOD1 mutations in ALS, focusing on toxic gain of function, protein misfolding, and non-cell autonomous disease.

Protein Quality Control of Membraneless Organelles

Explores protein quality control in membraneless organelles and its implications for diseases.

Deleterious Phase Transitions in ALS/FTD

Explores the connection between ALS and FTD, focusing on genetic overlap, protein inclusions, and therapeutic strategies.

The Molecular Interactions that Shape Tau Polymorphs

Explores the molecular interactions shaping tau polymorphs and the role of Hsp40s in regulating tau aggregation.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Proteome Foldedness & Aggregation: Surveying Proteostasis Stress

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Cryo-EM and Parkinson's Disease

Delves into Cryo-EM's role in studying Parkinson's Disease and protein structures at the nano-level.

Molecular Chaperone Action: Small Heat Shock Proteins

Explores the molecular chaperone action of small heat shock proteins in proteostasis, focusing on their interaction with misfolded proteins and amyloid fibrils.

Parkinson's Disease: Genetic Factors

Explores genetic factors in Parkinson's disease, focusing on a-synuclein, Parkin, and PINK1, and their impact on mitochondrial quality control.

Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions

Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.