Lectures related to Protein-Repair Machineries: Evolution and Function

Protein Folding: Non-equilibrium Dynamics

Explores protein folding dynamics, focusing on chaperone-assisted non-equilibrium stabilization and its implications for biophysics and evolution.

Biological Contaminants: Pathogens

Covers the definition of biological contaminants and the transmission of pathogens, including emerging infectious diseases and antibiotic resistance.

Protein Folding Dynamics

Explores protein folding dynamics, chaperones, ATP hydrolysis, and DNA folding intricacies within the nucleus.

Proteome Foldedness & Aggregation: Surveying Proteostasis Stress

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Hsp70 Molecular Chaperones: Conformational Flexibility and Function

Explores the conformational and functional flexibility of Hsp70 molecular chaperones, focusing on folding intermediates and the Hsp70 functional cycle.

Metabolism and Proteostasis Evolution

Explores the connection between metabolism and proteostasis evolution, focusing on protein biogenesis, mutational buffering, and metabolite impact.

Protein Folding: Chaperone Solutions

Explores chaperones' role in guiding protein folding and preventing misfolding through the functional cycle of Hsp70 and the DnaK chaperone system.

Molecular Mechanism of Chaperonin GroEL

Explores the molecular mechanism and client preference of chaperonin GroEL in protein folding and aggregation prevention.

Molecular Chaperone Action: Small Heat Shock Proteins

Explores the molecular chaperone action of small heat shock proteins in proteostasis, focusing on their interaction with misfolded proteins and amyloid fibrils.

Non-refoldability in E. coli Proteome

Delves into non-refoldability in the E. coli proteome, exploring protein folding challenges and implications.

Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Membrane Protein Quality Control at ER

Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.

Protein Polymers: Biophysics Insights

Delves into protein polymers, discussing co-evolution, diffusion, protein structures, and experimental methods.

Energy Minimization in Biological Systems: Equilibrium Models

Covers energy minimization models in biological systems, focusing on equilibrium and the roles of entropy and hydrophobicity.

Proteins: Central Dogma and Translation

Explains protein synthesis, translation, and the central dogma of molecular biology.

Protein Labeling Techniques

Covers protein labeling techniques using self-labeling parts like FIASH and SNAP.

Proteostasis Regulation: Chaperone Interactions and Post-Translational Modifications

Explores proteostasis regulation through chaperone interactions and post-translational modifications, revealing insights into protein quality control mechanisms.

Protein Co-evolution Analysis

Delves into protein co-evolution analysis, covering discoveries, residue contacts, and direct coupling analysis.

Protein Folding: Structure and Design

Explores protein folding, hydrophobic interactions, compact conformations, the HP model, co-evolution, and computational methods.