Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.
Explores the selection and rationale behind preclinical animal models in drug discovery, emphasizing understanding mechanisms of action and domain specificity.
Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.
Covers Parkinson's disease, its symptoms, diagnosis challenges, and current treatment options, emphasizing the need for early biomarkers and disease-modifying therapies.
Explores Tau pathologies in Alzheimer's and related disorders, covering hyperphosphorylation, propagation, genetic associations, and therapeutic interventions.
Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.
Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.
Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.
