Explores Alzheimer's disease, anxiety, pain, and the renin-angiotensin system, including the development of the first renin inhibitor for clinical treatment.
Explores enzyme activity modulation and small-molecule drug mechanisms, focusing on reversible and irreversible inhibition, progress curves, and covalent bond formation.
Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
Explores the regulation of the urinary system, including the role of vasa recta and ADH in water reabsorption, circulatory volume control, and blood pH stabilization.
