Publications by Jutta Christine Wandrey

Strategies to Functionalize the Anionic Biopolymer Na-Alginate Without Restricting its Polyelectrolyte Properties

Jutta Christine Wandrey, Sandrine Gerber, Luca Szabó

The natural anionic polyelectrolyte alginate and its derivatives are of particular interest for pharmaceutical and biomedical applications. Most interesting for such applications are alginate hydrogels, which can be processed into various shapes, self-stan ...

2020

Hydrogels based on functionalized polysaccharides

Jutta Christine Wandrey, Sandrine Gerber, Léo Bühler, Solène Marcelle Françoise Marie Passemard

The present invention relates to functionalized hydrogel networks grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine. ...

2018

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou

Background: Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets. Methods: Human MSC ...

Biomed Central Ltd2017

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Jutta Christine Wandrey, Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

American Chemical Society2017

Hydrogels based on functionalized polysaccharides

Jutta Christine Wandrey, Sandrine Gerber, Léo Bühler, Solène Marcelle Françoise Marie Passemard

The present invention relates to a functionalized hydrogel network grafted with at least one moiety for use in numerous fields, from cosmetics to surgery and medicine. ...

Technology Transfer Office EPFL, Swiss Federal Institute of Intellectual Property2016

Effect of Very High Charge Density and Monomer Constitution on the Synthesis and Properties of Cationic Polyelectrolytes

Jutta Christine Wandrey, Ricardo Losada Mateo, Hamideh Ahmadloo

The free-radical homopolymerization of 1,3-bis(N,N,N-trimethylammonium)-2-propylmethacrylate dichloride (di-M) and 1,3-bis(N,N,N-trimethylammonium)-2-propylacrylate dichloride (di-A) in aqueous solution yields cationic polyelectrolytes (PEL) with theoretic ...

Mdpi Ag2016

Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact

Jutta Christine Wandrey, Redouan Mahou

Wiley-Blackwell2016

Contribution of polymeric materials to progress in xenotransplantation of microencapsulated cells - A review

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Cell microencapsulation and subsequent transplantation of the microencapsulated cells require multidisciplinary approaches. Physical, chemical, biological, engineering, and medical expertise has to be combined. Several natural and synthetic polymeric mater ...

2016

Human mesenchymal stromal cells improve survival and function of pancreatic iislets by cell-to-cell contact through N-cadherin

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Wiley-Blackwell2015

Human mesenchymal stromal cells improve survival and function of pancreatic islets by cell-to-cell contact

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou

Wiley-Blackwell2015

Human Mesenchymal Stromal Cells Improve Survival And Function Of Pancreatic Islets By Cell-To-Cell Contact

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Léo Bühler, Solène Marcelle Françoise Marie Passemard

Wiley-Blackwell2015

A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation

Jutta Christine Wandrey, Helmut Coelfen, Ahmet Bekdemir

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this ...

Public Library of Science2015

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Françoise Borcard, Léo Bühler, François Rémi Pierre Noverraz, Virginia Crivelli, Solène Marcelle Françoise Marie Passemard

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Correlation between flocculation and adsorption of cationic polyacrylamides on precipitated calcium carbonate

David Hunkeler, Jutta Christine Wandrey, Hamideh Ahmadloo, Ineide Cruz Pinheiro

The study of each stage of the flocculation process is essential to better understand and predict flocculation mechanisms. The adsorption of cationic polyacrylamide derivatives (C-PAM) onto precipitated calcium carbonate (PCC) has been investigated systema ...

Inst Chemical Engineers2015

Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice

Jutta Christine Wandrey, Yannick Müller, Redouan Mahou

Background & Aims: Mesenchymal stem cell (MSC) transplantation was shown to be effective for the treatment of liver fibrosis, but the mechanisms of action are not yet fully understood. We transplanted encapsulated human MSCs in two mouse models of liver fi ...

Elsevier Science Bv2015

Human Mesenchymal Stromal Cells Improve Survival And Function Of Pancreatic Iislets By Cell-To-Cell Contact Through N-Cadherin

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

Lippincott Williams & Wilkins2015

Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers

Jutta Christine Wandrey, Lucia Baldi Unser, Sagar Shashidhar Manoli, Nino Zavradashvili, Tamar Memanishvili

The success of gene therapy depends on safe and effective gene carriers. Despite being widely used, synthetic vectors based on poly(ethylenimine) (PEI), poly(l-lysine) (PLL), or poly(l-arginine) (poly-Arg) are not yet fully satisfactory. Thus, both improve ...

American Chemical Society2014

Cell Compatible Arginine Containing Cationic Polymer: One-Pot Synthesis and Preliminary Biological Assessment

Jutta Christine Wandrey, Lucia Baldi Unser, Xiao Shen, Nino Zavradashvili, Tamar Memanishvili

Synthetic cationic polymers are of interest as both nonviral vectors for intracellular gene delivery and antimicrobial agents. For both applications synthetic polymers containing guanidine groups are of special interest since such kind of organic compounds ...

Springer India2014

Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation

Jutta Christine Wandrey, Redouan Mahou

The progress of medical therapies, which rely on the transplantation of microencapsulated living cells, depends on the quality of the encapsulating material. Such material has to be biocompatible, and the microencapsulation process must be simple and not h ...

Mdpi Ag2014

Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow

Jutta Christine Wandrey, Yannick Müller, Redouan Mahou

Bone marrow was recently proposed as an alternative and potentially immune-privileged site for pancreatic islet transplantation. The aim of the present study was to assess the survival and rejection mechanisms of free and encapsulated xenogeneic islets tra ...

Public Library of Science2014