Publications by Arnaud Bertsch

Additive manufacturing of water-soluble 3D micro molds for complex-shaped lipid microparticles

Arnaud Bertsch, Jürgen Brugger, Jongeon Park

Micro and nanoparticles made from polymers, metals, ceramics, and lipids are crucial for biomedical devices, energy storage, and electronics. Traditional fabrication methods like grinding, milling, and emulsification result in monolithic shapes and heterog ...

2025

Combination of Thermal Scanning Probe Lithography and Directed Self-Assembly of Block Copolymers

Arnaud Bertsch, Jürgen Brugger, Berke Erbas

The fabrication of semiconductor quantum devices necessitates sub-20 nm features and high-density patterning, often exceeding the capabilities of current state-of-the-art lithographic techniques. To address this challenge, in this work, the combination of ...

SPIE2025

Electrical Stimulation of Trigeminal Nerve at the Anterior Nasal Septum in Healthy Individuals and Patients With Olfactory Dysfunction

Arnaud Bertsch, Clémentine Sophie Sarah Lipp

Background: The intranasal trigeminal system contributes to the sense of smell. Its integrity in olfactory dysfunction (OD) may be crucial for future treatments. This study assessed trigeminal sensitivity in healthy individuals and patients with OD of diff ...

2025

Beyond the Mask: Advancing Fabrication and Immersive Learning

Arnaud Bertsch, Jürgen Brugger, Berke Erbas, Jongeon Park, Chenxiang Zhang

This paper presents advances in micro and nanofabrication techniques beyond conventional lithographic masks with examples of inkj et printing, nanostencil lithography, molecular-level doping methods, and thermal scanning probe lithography. These methods en ...

IEEE2025

3D Lipid Microrobots for Simultaneous Delivery of Lipophilic and Hydrophilic Drugs

Arnaud Bertsch, Jürgen Brugger, Jongeon Park

This study presents the development of a 3D lipid microhelix capable of simultaneously delivering drugs with different characteristics, including water-soluble and poorly water-soluble drugs. Lipid microhelix encapsulating magnetic nanoparticles (MNPs) and ...

IEEE2025

Performance Comparison of Shape Memory Polymer Structures Printed by Fused Deposition Modeling and Melt Electrowriting

Arnaud Bertsch, Jürgen Brugger, Taavet Kangur, Reza Farsi, Biranche Tandon

Fused deposition modeling (FDM) and melt electrowriting (MEW) are techniques that use polymer fibers as building blocks for printing complex 3D structures, with fibers at the macroscopic and micrometer scale. Here, FDM and MEW are used to produce fibers of ...

Wiley2024

Microstructured plastic scintillators for pencil beam profiling in proton-therapy accelerators

Arnaud Bertsch, Alessandro Mapelli, Fabrizio Carbone, Simone Gargiulo, Veronica Leccese

A novel beam profiler based on microstructured scintillation resin is presented. The detector consists of a bundle of waveguides, featuring an active area of 30 x 30 mm2 with a fill factor of 50% and a pitch of 400 mu m. This configuration is obtained by c ...

Elsevier2024

Devices for the electrical stimulation of the olfactory system: A review

Arnaud Bertsch, Jürgen Brugger, Clémentine Sophie Sarah Lipp

The loss of olfactory function has a profound impact on quality of life, affecting not only sensory perception but also memory, emotion, and overall well-being. Despite this, advancements in olfactory prostheses have lagged significantly behind those made ...

Elsevier2024

Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

Giovanni Boero, Arnaud Bertsch, Andras Kis, Jürgen Brugger, Georg Fantner, Zhenyu Wang, Xia Liu, Ana Conde Rubio, Berke Erbas, Mitali Banerjee, Marcos Penedo Garcia

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and fluidics. Thermal scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm, but its maxi ...

Springernature2024

Electrowriting of SU-8 Microfibers

Arnaud Bertsch, Sébastien Jiguet, Jürgen Brugger, Christophe Moser, Niyazi Ulas Dinç, Jorge Andres Madrid Wolff, Diego Armando Sandoval Salaiza

As microfiber-based additive manufacturing (AM) technologies, melt electrowriting (MEW) and solution electrowriting (SEW) have demonstrated efficacy with more biomedically relevant materials. By processing SU-8 resin using MEW and SEW techniques, a materia ...

MDPI AG2024

Hot topic: Mapping of the human intranasal mucosal thermal sensitivity: A clinical study on thermal threshold and trigeminal receptors

Arnaud Bertsch, Evgenii Glushkov

Introduction The olfactory and trigeminal system are closely interlinked. Existing literature has primarily focused on characterizing trigeminal stimulation through mechanical and chemical stimulation, neglecting thermal stimulation thus far. The present s ...

2024

High-resolution scintillation detector for two-dimensional reconstruction

Arnaud Bertsch, Alessandro Mapelli, Fabrizio Carbone, Veronica Leccese

A scintillation device including a silicon plate having a rectangular shape and having a first side and a second side opposite the first side, wherein the first side includes a plurality of first channels arranged to be in parallel with each other extendin ...

2023

Rapid exocytosis kinetics measured by amperometry within volcano microelectrodes

Philippe Renaud, Arnaud Bertsch, Nicolas Grégoire Maïno

For over 30 years, carbon fiber microelectrodes have been the gold standard for measurements related to exocytosis and more generally to the processes taking place at the synaptic level. However, this method has a low throughput and molecules can escape de ...

ROYAL SOC CHEMISTRY2023

Method for manufacturing an active structure for a radiation detector and polymeric mold for the method

Arnaud Bertsch, Alessandro Mapelli, Fabrizio Carbone, Veronica Leccese

A method for manufacturing a scintillation detector structure including the steps of forming a plurality of first structures into a surface of a substrate to form a patterned substrate, filling the plurality of first structures and covering the surface of ...

2023

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Philippe Renaud, Arnaud Bertsch, Clémentine Sophie Sarah Lipp

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

ROYAL SOC CHEMISTRY2023

Breaking one into three: Surface-tension-driven droplet breakup in T-junctions

Philippe Renaud, Arnaud Bertsch, François Gallaire, Daniel Migliozzi, Yves-Marie François Ducimetière, Jiande Zhou, Ludovic Pierre Gustave Keiser

Droplet breakup is an important phenomenon in the field of microfluidics to generate daughter droplets. In this work, a novel breakup regime in the widely studied T-junction geometry is reported, where the pinch-off occurs laterally in the two outlet chann ...

AMER PHYSICAL SOC2023

Aperture-Controlled Fabrication of All-Dielectric Structural Color Pixels

Philippe Renaud, Arnaud Bertsch, Olivier Martin, Daniel Migliozzi, Clémentine Sophie Sarah Lipp, Evgenii Glushkov, Hsiang-Chu Wang, Audrey Zoé Marie Jacquillat

While interference colors have been known for a longtime, conventionalcolor filters have large spatial dimensions and cannot be used tocreate compact pixelized color pictures. Here we report a simple yetelegant interference-based method of creating microsc ...

AMER CHEMICAL SOC2023

Liquid-in-a-MEMS: Encapsulation of Liquid in a Microcapsule by Inkjet Printing

Arnaud Bertsch, Jürgen Brugger, Jongeon Park

IEEE2023

Impedance spectroscopy of the cell/nanovolcano interface enables optimization for electrophysiology

Philippe Renaud, Arnaud Bertsch, Nicolas Grégoire Maïno

Volcano-shaped microelectrodes have demonstrated superior performance in measuring attenuated intracellular action potentials from cardiomyocyte cultures. However, their application to neuronal cultures has not yet yielded reliable intracellular access. Th ...

SPRINGERNATURE2023

Nanoliter Liquid Packaging in a Bioresorbable Microsystem by Additive Manufacturing and its Application as a Controlled Drug Delivery Device

Arnaud Bertsch, Jürgen Brugger, Cristina Martin Olmos, Jongeon Park

Precise packaging of nanoliter amounts of liquid in a microsystem is important for many biomedical applications. However, existing liquid encapsulation technologies have limitations in terms of liquid waste, evaporation, trapped bubbles, and liquid degrada ...

2023