Publications by Geoffrey Bodenhausen

Gunther Laukien Prize 2019

Wiley-VCH Verlag GmbH2019

Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Basile Vuichoud, Daniele Mammoli, Arthur César Pinon, Gabriele Stevanato

We have induced hyperpolarized long-lived states in compounds containing C-13-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyper polarized methyl long-lived states g ...

Amer Chemical Soc2017

Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, Xiao Ji, David Lyndon Emsley, Aaron James Rossini

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Baudouin

Hyperpolarization of NMR-active nuclei is key to gather high quality spectra of rare species and insensitive isotopes. We have recently established that silica-based materials containing regularly distributed nitroxyl radicals connected to the silica matri ...

Wiley-V C H Verlag Gmbh2017

Exciting Wide NMR Spectra of Static Solid Samples with Weak Radiofrequency Fields

Geoffrey Bodenhausen, Diego Carnevale, Srinivas Chinthalapalli

Trains of short pulses in the manner of `delays alternating with nutations for tailored excitation' (DANTE) have been applied to the Pake patterns of protons of water molecules trapped in a static powdered sample of barium chlorate monohydrate. The spin dy ...

Walter De Gruyter Gmbh2017

Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Dynamic Nuclear Polarization (DNP) is often achieved by the direct transfer of polarization from electrons to nuclei such as C-13, induced by microwave saturation of the wings of narrow EPR lines of radicals like trityl. In the indirect approach on the oth ...

Amer Inst Physics2017

Transportable long-lived hyperpolarized samples

Geoffrey Bodenhausen, Sami Jannin, David Lyndon Emsley

A method for the preparation of a hyperpolarized solution of molecules comprises the steps: 1) suspending or coating of a micro-particulate matrix, which is comprising or consisting of the molecules, with a glass-forming solution or suspension comprising a ...

2016

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Geoffrey Bodenhausen, Sami Jannin, Jonas Milani, Sina Marhabaie, Daniel Abergel, Estel Canet Martinez, Matthias Weller

We present novel means to hyperpolarize deuterium nuclei in (CD2)-C-13 groups at cryogenic temperatures. The method is based on cross-polarization from H-1 to C-13 and does not require any radio-frequency fields applied to the deuterium nuclei. After rapid ...

Amer Inst Physics2016

Ligand-Protein Affinity Studies Using Long-Lived States of Fluorine-19 Nuclei

Geoffrey Bodenhausen, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

The lifetimes T-LLS of long-lived states or T-LLC of long-lived coherences can be used for the accurate determination of dissociation constants of weak protein ligand complexes. The remarkable contrast between signals derived from LLS or LLC in free and bo ...

American Chemical Society2016

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016

Structured and porous materials particularly suitable as polarizing agents in dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, David Benjamin Roger Antoine Gajan, David Lyndon Emsley, David Baudouin

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other by oxy bridges, comprising organic molecules which include at ...

2016

The effects of molecular diffusion in spatially encoded magnetic resonance imaging

Geoffrey Bodenhausen, Sina Marhabaie

In spatially encoded MRI, the signal is acquired sequentially for different coordinates. In particular for single-scan acquisitions in inhomogeneous fields, spatially encoded methods improve the image quality compared to traditional k-space encoding. Previ ...

Academic Press Inc - Elsevier Science2016

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Robert Konrat, Jonas Milani, Pascal Miéville, Basile Vuichoud, Florian Patrick Marie Daniel De la Barre De Nanteuil, Xiao Ji, Estel Canet Martinez

Hyperpolarization is generated by dissolution dynamic nuclear polarization (d-DNP) using a polymer-based polarizing agent dubbed FLAP (filterable labeled agents for polarization). It consists of a thermo-responsive poly(N-isopropylacrylamide), also known a ...

Wiley-V C H Verlag Gmbh2016

Kinetic isotope effects for fast deuterium and proton exchange rates

Geoffrey Bodenhausen, Daniele Mammoli, Pavel Kaderavek, Estel Canet Martinez

By monitoring the effect of deuterium decoupling on the decay of transverse N-15 magnetization in D-N-15 spin pairs during multiple-refocusing echo sequences, we have determined fast D-D exchange rates k(D) and compared them with fast H-H exchange rates k( ...

Royal Society of Chemistry2016

Collisional cross-section of water molecules in vapour studied by means of H-1 relaxation in NMR

Geoffrey Bodenhausen, Lothar Helm, Pascal Miéville, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

In gas phase, collisions that affect the rotational angular momentum lead to the return of the magnetization to its equilibrium (relaxation) in Nuclear Magnetic Resonance (NMR). To the best of our knowledge, the longitudinal relaxation rates R-1 = 1/T-1 of ...

Nature Research2016

Microwave-gated dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Xiao Ji, Arthur César Pinon, David Lyndon Emsley, Mathieu Baudin

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P(C-13) in short bu ...

Royal Society of Chemistry2016

Homonuclear decoupling for spectral simplification of carbon-13 enriched molecules in solution-state NMR enhanced by dissolution DNP

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Diego Carnevale, Srinivas Chinthalapalli

Complex overlapping multiplets due to scalar couplings (n)J(C-13, C-13) in fully C-13-enriched molecules can be simplified by polychromatic irradiation of selected spins. The signal intensities of the remaining non-irradiated signals are proportional to th ...

Royal Society of Chemistry2016

Nuclear overhauser spectroscopy of chiral CHD methylene groups

Geoffrey Bodenhausen, Fabien Ferrage

Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion ...

Springer Verlag2016

Lifetimes of long-lived states in inhomogeneous magnetic fields

Geoffrey Bodenhausen, Srinivas Chinthalapalli, Maninder Singh

Long-lived states (LLS), also known as singlet states, have been widely studied in the last decade. So far, LLS have only been observed in homogeneous magnetic fields, which preclude applications to many biological samples that are inherently inhomogeneous ...

Elsevier2015

Rotation-induced recovery and bleaching in magnetic resonance

Geoffrey Bodenhausen, Diego Carnevale, Srinivas Chinthalapalli, Angel Joaquin Perez Linde

Thurber and Tycko recently described a 'bleaching effect' that occurs in magnetic resonance when solid samples that are doped with paramagnetic agents are subjected to rotation by magic angle spinning (MAS) in a static magnetic field with a rotation period ...

Royal Society of Chemistry2015