Publications by Nicolas Kunz | EPFL Graph Search

Design of an elastic porous injectable biomaterial for tissue regeneration and volume retention

Soft tissue reconstruction currently relies on two main approaches, one involving the implantation of ex-ternal biomaterials and the second one exploiting surgical autologous tissue displacement. While both methods have different advantages and disadvantag ...

ELSEVIER SCI LTD2022

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Nicolas Kunz, Tobias Kober, Alessandro Daducci, Tom Hilbert, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

Nicolas Kunz, Olivier Burri, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos, Chiheb Boussema, Frédérica Schyrr, Josefine Catharina Pedersen Tratwal, Shanti Rojas-Sutterlin, Rita Sarkis, Daniel Naveed Tavakol

The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...

2020

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance

Arnaud Comment, Nicolas Kunz, Mor-Miri Mishkovsky, Emine Can, Hikari Ananda Infinity Yoshihara

The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted with various techniques and reported in ...

Nature Research2020

MarrowQuant across Aging and Aplasia: A Digital Pathology Tool for Quantification of Bone Marrow Compartments in Histological Sections

Nicolas Kunz, Olivier Burri, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos, Frédérica Schyrr, Josefine Catharina Pedersen Tratwal, Shanti Rojas-Sutterlin, Rita Sarkis

WILEY2020

Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Nicolas Kunz, François Lazeyras, Laura Ioana Gui

Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to ...

2020

Diffusion behavior of cerebral metabolites of congenital portal systemic shunt mice assessed noninvasively by diffusion-weighted H-1 magnetic resonance spectroscopy

Nicolas Kunz, Hongxia Lei, Masoumeh Dehghani Moghadam

Diffusion-weighted H-1-MRS (DW-MRS) allows for noninvasive investigation of the cellular compartmentalization of cerebral metabolites. DW-MRS applied to the congenital portal systemic shunt (PSS) mouse brain may provide specific insight into alterations of ...

2019

Neuronal energy metabolism in the mouse brain measured by H-1-[C-13] MRS at 14.1T under [3-C-13]-Lactate infusion: a feasibility study

Nicolas Kunz, Bernard Lanz, Lijing Xin, Hongxia Lei

SAGE PUBLICATIONS INC2019

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

Jean-Philippe Thiran, Nicolas Kunz, Alessandro Daducci, Erick Jorge Canales Rodriguez, Marco Pizzolato

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

2018

Intra- and extra-axonal axial diffusivities in the white matter: Which one is faster?

Nicolas Kunz, Ileana Ozana Jelescu

A two-compartment model of diffusion in white matter, which accounts for intra- and extra-axonal spaces, is associated with two plausible mathematical scenarios: either the intra-axonal axial diffusivity Da,‖ is higher than the extra-axonal De,‖ (Branch 1) ...

2018

Comparison diffusion behavior of metabolites in brains of congenital portal systemic shunt and healthy mice in vivo at 14.1 t

Nicolas Kunz, Rolf Gruetter, Hongxia Lei, Masoumeh Dehghani Moghadam

Wiley2017

Diffusion-weighted MRS of acetate in the rat brain

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, Masoumeh Dehghani Moghadam, Hikari Ananda Infinity Yoshihara

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Wiley-Blackwell2017

Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Masoumeh Dehghani Moghadam

Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Sage Publications Ltd2016

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Nicolas Kunz, Rolf Gruetter

Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...

Nature Publishing Group2014

Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging

Jean-Philippe Thiran, Nicolas Kunz, François Lazeyras, Alia Lemkaddem, Alessandro Daducci

Focal epilepsy is increasingly recognized as the result of an altered brain network, both on the structural and functional levels and the characterization of these widespread brain alterations is crucial for our understanding of the clinical manifestation ...

2014

Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models

Nicolas Kunz, François Lazeyras, Kieran O'Brien, Hui Zhang

Brain white matter connections have become a focus of major interest with important maturational processes occurring in newborns. To study the complex microstructural developmental changes in-vivo, it is imperative that non-invasive neuroimaging approaches ...

Elsevier2014

Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

The recent developments in high magnetic field (13) C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of (13) C in vivo spectra in the rodent brain, enabl ...

Wiley-Blackwell2013

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

Nicolas Kunz, Rolf Gruetter, Yohan Van de Looij

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

Wiley-Blackwell2013

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla

Nicolas Kunz, Rolf Gruetter, Benoît Schaller, Lijing Xin

After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMR(Glc) ) in excess of those in oxygen (CMR(O2) ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, r ...

Wiley-Blackwell2013

In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure

Nicolas Kunz, Rolf Gruetter, Yohan Van de Looij, Cristina Ramona Cudalbu

2012