Publications by Alke Fink | EPFL Graph Search

The need for awareness and action in managing nanowaste

Waste containing nanomaterials — or nanowaste — is an emerging safety concern worldwide, warranting specific environmentally sound waste management and regulation. ...

2023

NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities

Thierry Meyer, Alke Fink, Anna Maria Novello, Elina Buitrago

Research in nanoscience continues to bring forward a steady stream of new nanomaterials and processes that are being developed and marketed. While scientific committees and expert groups deal with the harmonization of terminology and legal challenges, risk ...

2021

An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells

Alke Fink, Pablo Campomanes Ramos, Stefano Vanni, Francesco Stellacci

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequ ...

SWISS CHEMICAL SOC2019

Recent advances in nano-bio-interactions: Editorial

Paul Bowen, Alke Fink, Sami Rtimi

ELSEVIER SCIENCE BV2019

Cellulose Nanocrystals with Tethered Polymer Chains: Chemically Patchy versus Uniform Decoration

Alke Fink, Harm-Anton Klok, Théo Gaston Gérard Lachat, Justin Orazio Zoppe, Alix Vaimiti Marie Dupire

The site-specific surface modification of colloidal substrates, yielding "patchy" nanoparticles, is a rapidly expanding area of research as a result of the new complex structural hierarchies that are becoming accessible to chemists and materials scientists ...

2017

Engineered nanomaterials: toward effective safety management in research laboratories

Heinrich Hofmann, Thierry Meyer, Amela Groso, Alke Fink

Background: It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is ...

BioMed Central2016

MULTIFUNCTIONALIZED SPIONs FOR NUCLEAR TARGETING: CELL UPTAKE AND GENE EXPRESSION

Heinrich Hofmann, Alke Fink, Jatuporn Salaklang

Superparamagnetic iron oxide nanoparticles (SPIONs) are used in many biological applications, which necessitate intracellular targeting. Here, we investigate intracellular localization and gene expression in HeLa cells after treatment with functionalized S ...

World Scientific Publ Co Pte Ltd2014

Spatial SPION Localization in Liposome Membranes

Alke Fink, Davide Demurtas

Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the ...

Institute of Electrical and Electronics Engineers2013

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro

Alke Fink, Marc Moniatte

It is known that the nanoparticle-cell interaction strongly depends on the physicochemical properties of the investigated particles. In addition, medium density and viscosity influence the colloidal behaviour of nanoparticles. Here, we show how nanoparticl ...

Royal Soc Chemistry2013

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Heinrich Hofmann, Alke Fink, Jatuporn Salaklang

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging p ...

Wiley-Blackwell2012

Erratum to "Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia" (vol 323, pg 1054, 2011)

Olivier Jordan, Heinrich Hofmann, Alke Fink

2011

Safety management of nanomaterials

Thierry Meyer, Amela Groso, Alke Fink, Arnaud Magrez

2011

The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia

Olivier Jordan, Heinrich Hofmann, Antonin Faes, Alke Fink, Daniel Ruefenacht

In situ forming implants are attractive for minimally invasive localized therapies such as aneurysm embolization. As for the superparamagnetic iron oxide nanoparticles (SPIONs), their deposition/injection in a target tissue area allows magnetically induced ...

2010

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Heinrich Hofmann, Alke Fink, Jean-Noël Hyacinthe

To evaluate the feasibility of loading resting monocytes/macrophages by intravenous (i.v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic reson ...

Oxford University Press2010

Control of morphology and nanostructure of copper and cobalt oxalates: Effect of complexing ions, polymeric additives and molecular weight

Nathalie Jongen, Paul Bowen, Heinrich Hofmann, Jacques Lemaître, Alke Fink

Precipitated oxalates are often nanostructured and can be used as precursors for nanostructured oxides for different applications. The modification of the particle shape and nanostructures of both copper and cobalt oxalates has been demonstrated using poly ...

2010

Exposure to super-paramagnetic iron oxide nanoparticles reduces dendritic cell-dependent antigen-specific T-cell proliferation

Heinrich Hofmann, Alke Fink

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2009

Particle Size Distribution Measurements of Manganese-Doped ZnS Nanoparticles

Heinrich Hofmann, Alke Fink

We performed particle size and particle size distribution measurements for L-cysteine-stabilized ZnS/Mn nanoparticles in the size region below 10 nm. For this we applied transmission electron microscopy (TEM), analytical ultracentrifugation (AUC), dynamic ...

2009

Magnetic, paramagnetic and/or superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The present invention relates to nanoparticles having a mean diameter of < 500nm and comprising, at their surface, a selected material. The nanoparticles are taken up by cells under physiological conditions and can be used to isolate interaction partners o ...

2009

Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model

Olivier Jordan, Heinrich Hofmann, Alke Fink

Purpose: We investigate a new heat delivery technique for the local treatment of solid tumors. The technique involves injecting a formulation that solidifies to form an implant in situ. This implant entraps superparamagnetic iron oxide nanoparticles (SPION ...

Taylor & Francis2009

Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): Colloidal stability, cytotoxicity, and cellular uptake studies

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Andrija Finka, Jatuporn Salaklang

The influence of the composition of the polymer coated polyvinyl alcohol (PVA), vinyl alcohol/vinyl amine copolymer (A-PVA) and polyethylenimine (PEI) coated superparamagnetic iron oxide nanoparticles (SPIONs) on the colloidal stability, cytotoxicity and c ...

2008