Publications by Anne Thérèse Sigstam

Viruses at solid-water interfaces: A systematic assessment of interactions driving adsorption

Anne Thérèse Sigstam, Tamar Kohn, Antonius Magdi Hakeem Armanious, Dominik Refardt, Meret Aeppli

Adsorption to solid-water interfaces is a major process governing the fate of waterborne viruses in natural and engineered systems. The relative contributions of different interaction forces to adsorption and their dependence on the physicochemical propert ...

Amer Chemical Soc2016

On the cause of the tailing phenomenon during virus disinfection by chlorine dioxide

Anne Thérèse Sigstam, Tamar Kohn, Moritz Brennecke, Qingxia Zhong, Andreas Rohatschek

This study investigates the mechanisms underlying the deviation from Chick-Watson kinetics, namely a tailing curve, during the disinfection of viruses by chlorine dioxide (ClO2). Tailing has been previously reported, but is typically attributed to the deca ...

Elsevier2014

Mechanistic insight into virus disinfection : influence of virus characteristics, solution composition and surface interactions

Anne Thérèse Sigstam

EPFL2014

Subtle differences in virus composition affect disinfection kinetics and mechanisms

Anne Thérèse Sigstam, Michele Cascella, Tamar Kohn, Brian Pecson, Krista Rule Wigginton

Viral disinfection kinetics have been studied in depth, but the molecular-level inactivation mechanisms are not understood. Consequently, it is difficult to predict the disinfection behavior of non-culturable viruses, even when related, culturable viruses ...

American Society for Microbiology2013

Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity

Anne Thérèse Sigstam, Tamar Kohn, Brian Pecson, Krista Rule Wigginton, Franziska Sara Bosshard

Oxidative processes are often harnessed as tools for pathogen disinfection. Although the pathways responsible for bacterial inactivation with various biocides are fairly well understood, virus inactivation mechanisms are often contradictory or equivocal. I ...

Amer Chemical Soc2012

Inactivation of bacteriophage MS2 with potassium ferrate(VI)

Anne Thérèse Sigstam, Tamar Kohn, Timothy Strathmann

Ferrate [Fe(VI); FeO42-] is an emerging oxidizing agent capable of controlling chemical and microbial water contaminants. Here, inactivation of MS2 coliphage by Fe(VI) was examined. The inactivation kinetics observed in individual batch experiments was wel ...

Amer Chemical Soc2012

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Hisham Ben Hamidane, Anne Thérèse Sigstam, Michele Cascella, Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

2012