Publications by Luc Patiny | EPFL Graph Search

Rapid Untargeted Puff-by-Puff Analysis of (Electronic) Cigarette Emissions by Concentric Dielectric Barrier Discharge Ionisation Mass Spectrometry

Luc Patiny, Laure Menin, Natalia Gasilova, Maria Pavlou

Despite the soaring popularity of e-cigarettes among teenagers and young adults, our understanding of the full extent of their health hazards have remained limited. This is due to the vast complexities of e-cigarette aerosols and the difficulty in their fu ...

2024

Two Decades of Online Teaching: Trends, Challenges, and Future Directions

Luc Patiny

Over the past two decades, significant advancements in educational technology have revolutionized the field of chemical education. This publication presents our contributions using web-based tools that have been developed over this period, enabling chemist ...

2023

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

Luc Patiny, Paul Joseph Dyson, Daniel Ortiz Trujillo, Laure Menin

Although genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corre ...

SPRINGER2022

Making the collective knowledge of chemistry open and machine actionable

Luc Patiny, Berend Smit, Kevin Maik Jablonka

Large amounts of data are generated in chemistry labs-nearly all instruments record data in a digital form, yet a considerable proportion is also captured non-digitally and reported in ways non-accessible to both humans and their computational agents. Chem ...

NATURE PORTFOLIO2022

Making Molecules Vibrate: Interactive Web Environment for the Teaching of Infrared Spectroscopy

Luc Patiny, Berend Smit, Kevin Maik Jablonka

Infrared spectroscopy (IR) is a staple structural elucidation and characterization technique because of its ability to identify functional groups and its ease of use. Interestingly, it allows the capture of electronic effects via their influence on the bon ...

AMER CHEMICAL SOC2022

A data-driven perspective on the colours of metal-organic frameworks

Luc Patiny, Seyedmohamad Moosavi, Berend Smit, Mehrdad Asgari, Christopher Patrick Ireland, Kevin Maik Jablonka

Colour is at the core of chemistry and has been fascinating humans since ancient times. It is also a key descriptor of optoelectronic properties of materials and is often used to assess the success of a synthesis. However, predicting the colour of a materi ...

2021

Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept

Luc Patiny, Daniel Ortiz Trujillo, Laure Menin, Francesco Stellacci, Anna Murello, Simone Giaveri, Shiyu Cheng

The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constant ...

Wiley2021

Participatory research to monitor lake water pollution

Luc Patiny, Rachel Aronoff, Carlos Vivar Rios

A participatory research team, concerned about water quality around Lake Geneva, particularly in the Montreux Bay region where some were lifeguards, ran sampling campaigns to determine summertime levels of lake water pollution. The participants were brough ...

WILEY2021

Aom(2)S: A new web-based application for DNA/RNA tandem mass spectrometry data interpretation

Luc Patiny, Francisco Sepulveda, Paul Joseph Dyson, Daniel Ortiz Trujillo, Laure Menin, Natalia Gasilova

Rationale The Analysis of Oligonucleotide Modifications from Mass Spectra (Aom(2)S) was created to support the analysis of oligonucleotide mass spectra. This application complements the existing software tools by providing a comprehensive analysis of oligo ...

WILEY2020

A biosensor for measuring NAD(+) levels at the point of care

Kai Johnsson, Luc Patiny, Elena Katsyuba, Johan Auwerx, Qiuliyang Yu, Lin Xue

The cellular level of nicotinamide adenine dinucleotide (NAD(+)), through its different functions, affects cellular metabolism and signalling(1-3). A decrease in the NAD(+) content has been associated with various pathologies and physiological aging(4,5), ...

NATURE PUBLISHING GROUP2019

Teaching NMR spectra analysis with nmr.cheminfo.org

Luc Patiny

2018

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public

Luc Patiny, Norman Pellet

2018

Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions

Luc Patiny, Paul Joseph Dyson, Laure Menin

Metallodrug protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with ...

2017

Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity

Luc Patiny, Paul Joseph Dyson, Laure Menin

RAPTA compounds, ([Ru(eta(6)-arene)(PTA)Cl-2], PTA = 1,3,5-triaza-7-phosphaadamantane), have been reported to overcome drug resistance in cisplatin resistant cells. However, the exact mechanism of these complexes is still largely unexplored. In this study, ...

Elsevier2017

Ask Erno: a self-learning tool for assignment and prediction of nuclear magnetic resonance spectra

Luc Patiny, Julien Wist, Andrés Mauricio Castillo Robles

Background: We present "Ask Erno", a self-learning system for the automatic analysis of NMR spectra, consisting of integrated chemical shift assignment and prediction tools. The output of the automatic assignment component initializes and improves a databa ...

Biomed Central Ltd2016

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Luc Patiny, Eileen Ryan, Anna Lee

The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explor ...

2016

Development of a systematic computer vision-based method to analyse and compare images of false identity documents for forensic intelligence purposes-Part I: Acquisition, calibration and validation issues

Thibault Genessay, Luc Patiny, Michaël Giuseppe Zasso, Marie Auberson, Simon Baechler

Following their detection and seizure by police and border guard authorities, false identity and travel documents are usually scanned, producing digital images. This research investigates the potential of these images to classify false identity documents, ...

Elsevier Ireland Ltd2016

Fully automatic assignment of small molecules' NMR spectra without relying on chemical shift predictions

Luc Patiny, Julien Wist, Andrés Mauricio Castillo Robles

We present a method for the automatic assignment of small molecules' NMR spectra. The method includes an automatic and novel self-consistent peak-picking routine that validates NMR peaks in each spectrum against peaks in the same or other spectra that are ...

Wiley-Blackwell2015

A virtual screening approach to identifying the greenest compound for a task: application to switchable-hydrophilicity solvents

Luc Patiny, Philip Gregory Jessop

A virtual or in silico screening approach makes it much easier to identify the molecular structure that best combines efficacy for a specific task with safety and minimum environmental or health impacts. In this approach, software is used to generate a lar ...

Royal Soc Chemistry2015

Wikipedia Chemical Structure Explorer: substructure and similarity searching of molecules from Wikipedia

Luc Patiny, Michaël Giuseppe Zasso

Background: Wikipedia, the world's largest and most popular encyclopedia is an indispensable source of chemistry information. It contains among others also entries for over 15,000 chemicals including metabolites, drugs, agrochemicals and industrial chemica ...

Biomed Central Ltd2015