Publications by Nicolas Christinat

Impact of multi-micronutrient supplementation on lipidemia of children and adolescents

Background: Micronutrient supplementation has been extensively explored as a strategy to improve health and reduce risk of chronic diseases. Fat-soluble vitamins like A and E with their antioxidant properties and mechanistic interactions with lipoproteins, ...

CHURCHILL LIVINGSTONE2020

Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patients

Nicolas Christinat, Sarah Catherine Sonnay, Anirikh Chakrabarti, Mojgan Masoodi

Background: Traumatic brain injury (TBI) is recognized as a metabolic disease, characterized by acute cerebral glucose hypo-metabolism. Adaptive metabolic responses to TBI involve the utilization of alternative energy substrates, such as ketone bodies. Cer ...

2019

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Nicolas Christinat, Rolf Gruetter, Lijing Xin, Maya Shevlyakova, Mojgan Masoodi, Özlem Ipek

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brains remain unclear. Here we report that ketones can increase ...

2018

Synthesis of Molecular Nanostructures by Multicomponent Condensation Reactions in a Ball Mill

Kay Severin, Rosario Scopelliti, Nicolas Christinat, Burçak Içli, Christian Schüttler, Justus Tönnemann

The condensation of multiple building blocks in a ball mill allows molecular cages with a size up to 3.1 nm to be built. ...

2009

Boron-Based Rotaxanes by Multicomponent Self-Assembly

Kay Severin, Rosario Scopelliti, Nicolas Christinat

Royal Society of Chemistry2008

Self-assembly of boron-based supramolecular structures

Nicolas Christinat

This work describes the synthesis and characterization of boronic acid-based supramolecular structures. Macrocycles, dendritic structures, polymers, rotaxanes, and cages were assembled using four types of reversible reactions. The key point of the strategy ...

EPFL2008

Multicomponent Assembly of Boronic Acid Based Macrocycles and Cages

Kay Severin, Rosario Scopelliti, Nicolas Christinat

Wiley-VCH Verlag GmbH2008

Multicomponent Assembly of Boron-Based Dendritic Nanostructures

Kay Severin, Rosario Scopelliti, Nicolas Christinat

2007

Formation of Boronate Ester Polymers with Efficient Intrastrand Charge Transfer Transitions by Three-Component Reactions

Kay Severin, Rosario Scopelliti, Nicolas Christinat, Ursula Röthlisberger, Emmanuel Croisier, Michele Cascella

The three-component reaction of aryl boronic acids with 1,2,4,5-tetrahydroxybenzene and 1,2-bis(4-pyridyl)ethylene or 4,4-bipyridine leads to the formation of dark-purple boronate ester polymers. Crystallographic analyses show that the polymer strands have ...

2007

A new method for the synthesis of boronate macrocycles

Kay Severin, Rosario Scopelliti, Nicolas Christinat

The condensation of aryl boronic acids with 2,3-dihydroxypyridine gives boronates, which self-assemble to form tetrameric macrocycles as evidenced by X-ray crystallographic analyses. ...

Royal Society of Chemistry2004