Publications by Darlene Goldstein

Automatic module selection from several microarray gene expression studies

Anthony Christopher Davison, Darlene Goldstein, Alix Corinne Josiane Colette Zollinger

2018

Meta-analysis of incomplete microarray studies

Anthony Christopher Davison, Darlene Goldstein, Alix Corinne Josiane Colette Zollinger

Meta-analysis of microarray studies to produce an overall gene list is relatively straightforward when complete data are available. When some studies lack information, for example, having only a ranked list of genes instead of complete primary data, it is ...

Oxford University Press2015

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Darlene Goldstein, Meredith Dixon

We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). ...

Soc Neuroscience2013

Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array

Darlene Goldstein

Epithelial ovarian cancer has the highest mortality rate among gynecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor-associated carbohydrate antigens. We investigated the potential of natural occurring ant ...

2012

Anti-glycan antibodies in epithelial ovarian cancer

Darlene Goldstein

Spandidos Publ Ltd2012

No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting

Darlene Goldstein

Objective. About 70% of epithelial ovarian cancer patients (EOC) are diagnosed at advanced stage with a five-year survival rate of only 30%. Whilst CA125 detects peritoneally-spread disease, it has limited sensitivity for early cancers, many of which are p ...

2011

Comparison of printed glycan array, suspension array and ELISA in the detection of human anti-glycan antibodies

Darlene Goldstein

Anti-glycan antibodies represent a vast and yet insufficiently investigated subpopulation of naturally occurring and adaptive antibodies in humans. Recently, a variety of glycan-based microarrays emerged, allowing high-throughput profiling of a large reper ...

2011

Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

Darlene Goldstein

Huntington disease (HD) is a fatal neurodegenerative disease with no effective treatment. In the R6/1 mouse model of HD, environmental enrichment delays the neurologic phenotype onset and prevents cerebral volume loss by unknown molecular mechanisms. We ex ...

Lippincott, Williams & Wilkins2010

Curvature and Strength of Ni-YSZ Solid Oxide Half-cells after RedOx Treatments

Antonin Faes, Andreas Kaiser, Darlene Goldstein

One of the main drawbacks of anode-supported solid oxide fuel cell technology is the limited capability to withstand reduction and oxidation (“RedOx”) of the Ni phase. This study compares the effect of RedOx cycles on curvature and strength of half-cells, ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2010

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Vlad Popovici, Jun Luo, Darlene Goldstein, Mauro Delorenzi, Lu Meng, Li Li, Li Zhang, Wen Luo, Li Guo, Jonathan Koh Boon Han, Wei Wang, Rui Jiang, Jie Liu, Ying Liu, Chenxu Zhao, Rong Chen

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to gene ...

Nature Publishing Group2010

Comprehensive analysis of Arabidopsis expression polymorphisms with simple inheritance

Darlene Goldstein

In Arabidopsis thaliana, gene expression level polymorphisms (ELPs) between natural accessions that exhibit simple, single locus inheritance are promising quantitative trait locus (QTL) candidates to explain phenotypic variability. It is assumed that such ...

2009

Selecting control genes for RT-QPCR using public microarray data

Vlad Popovici, Darlene Goldstein, Mauro Delorenzi

Background: Gene expression analysis has emerged as a major biological research area, with real-time quantitative reverse transcription PCR (RT-QPCR) being one of the most accurate and widely used techniques for expression profiling of selected genes. In o ...

2009

Proteogenomic studies in epithelial ovarian cancer: established knowledge and future needs

Darlene Goldstein

There has been a concerted effort over the last decade to improve our understanding of the complex biology of ovarian cancer. A linear growth in published proteogenomic studies has addressed a variety of questions regarding its molecular pathogenesis. A nu ...

2009

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

Thierry Sengstag, Darlene Goldstein, Benjamin Haibe-Kains, Mauro Delorenzi

Introduction Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance ...

2008

Quality Assessment for Short Oligonucleotide Microarray Data: Comment

Darlene Goldstein

American Statistical Association2008

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Thierry Sengstag, Darlene Goldstein, Mauro Delorenzi

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) a ...

Oxford University Press2007

Modulation of nucleosome dynamics in Huntington's disease

Darlene Goldstein

Oxford University Press2007

Regional and cellular gene expression changes in human Huntington's disease brain

Thierry Sengstag, Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

Partition resampling and extrapolation averaging: approximation methods for quantifying gene expression in large numbers of short oligonucleotide arrays

Darlene Goldstein

Oxford, Oxford University Press2006

A Laplace mixture model for the identification of differential expression in microarrays

Anthony Christopher Davison, Yann Ruffieux, Darlene Goldstein

Microarrays have become an important tool for studying the molecular basis of complex disease traits and fundamental biological processes. A common purpose of microarray experiments is the detection of genes that are differentially expressed under two cond ...

2006