Benjamin Blasco

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Related publications (4)

Functional Dissection of Intersubunit Interactions in the EspR Virulence Regulator of Mycobacterium tuberculosis

Giovanni Dietler, Benjamin Blasco, Stewart Cole, Florence Pojer, Matteo Dal Peraro, Basile Isidore Martin Wicky, Aleksandre Japaridze, Marco Stenta

The nucleoid-associated protein EspR, a chromosome organizer, has pleiotropic effects on expression of genes associated with cell wall function and pathogenesis in Mycobacterium tuberculosis. In particular, EspR binds to several sites upstream of the espAC ...

American Society for Microbiology2014

Structure-function analysis of the EspR virulence regulator of Mycobacterium tuberculosis

Benjamin Blasco

EPFL2014

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein

Benjamin Blasco, Stewart Cole, Claudia Sala, Florence Pojer, Jeffrey Chen, Swapna Uplekar, Jacques Rougemont, Ruben Hartkoorn

The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or neg ...

Public Library of Science2012

Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis

Benjamin Blasco, Stewart Cole, Florence Pojer, Jeffrey Chen

Mycobacterium tuberculosis (M. tb) the causative agent of tuberculosis (TB) causes 1.7 million deaths annually. According to the World Health Organization, in some areas of the world, 25% of TB cases are due to multi- or extensively drug resistant M. tb st ...

Elsevier2010

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