Cindy Fellay

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Related publications (5)

Detection of Drug-Protein Interactions with an Improved Yeast Three-Hybrid System

Cindy Fellay

The identification of the targets of therapeutic drugs is one of the major challenges for pharmaceutical companies. The main target responsible for drug action is often known, but most drugs also bind other targets, either causing deleterious side effects ...

EPFL2013

Total Synthesis of Cyrneine A

Cindy Fellay, Karl Gademann

The tricyclic diterpene cyrneine A featuring a hexatrienal unit was prepared synthetically for the first time by a Heck reaction, a carbene ring expansion, and a reductive carbonylation. The structure of the natural product was assigned by X‐ray crystal an ...

Wiley-VCH Verlag GmbH2012

Searching for the Protein Targets of Bioactive Molecules

Kai Johnsson, Christopher Chidley, Cindy Fellay, Miriam Grønlund Pedersen, Simone Moser, Hirohito Haruki

The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal phy ...

Schweizerische Chemische Gesellschaft2011

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Massimo Binaghi, Simone Bonazzi, Cindy Fellay, Karl Gademann, Jean-Yves Wach

Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an e ...

Georg Thieme Verlag2010

Indo-1 derivatives for local calcium sensing

Kai Johnsson, Cindy Fellay, Annina Aebischer

The role of calcium in signal transduction relies on the precise spatial and temporal control of its concentration. The existing means to detect fluctuations in Ca2+ concentrations with adequate temporal and spatial resolution are limited. We introduce her ...

American Chemical Society2009

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