Publications by Luigi Bonacina

Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics

Sandrine Gerber, Luigi Bonacina, Dario Diviani, Simon Kaiser, Jérémy Vuilleumier, Adrian Stefan Gheata

Nanoparticle-based drug delivery systems have the potential for increasing the efficiency of chemotherapeutics by enhancing the drug accumulation at specific target sites, therebyreducing adverse side effects and mitigating patient acquired resistance. In ...

2022

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Sandrine Gerber, Anne-Sophie Chauvin, Luigi Bonacina, Marinella Mazzanti, Katarzyna Pierzchala, Raphaël Jovita De Matos, Dario Diviani, Jérémy Vuilleumier, Adrian Stefan Gheata, Ileana Ozana Jelescu, Laura Camille Louise Nicolle, Fiorella Lucarini

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extend ...

2022

Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles

Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Raphaël Jovita De Matos, Jérémy Vuilleumier

While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy ...

Wiley-VHCA AG2020

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Luigi Bonacina, Daniel Ortiz Trujillo, Laure Menin, Raphaël Jovita De Matos, Jérémy Vuilleumier

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019

Publisher's Note: “Implications of short time scale dynamics on long time processes” (Struct. Dyn. 4, 061507 (2017)]

Majed Chergui, Ursula Röthlisberger, Luigi Bonacina, Cédric Schmidt, Swarnendu Bhattacharyya

2018

Multi-harmonic imaging in the second near-infrared window of nanoparticle-labeled stem cells as effective monitoring tool in tissue depth

Sandrine Gerber, Luigi Bonacina, Solène Marcelle Françoise Marie Passemard

In order to assess the therapeutic potential of cell-based strategies, it is of paramount importance to elaborate and validate new tools for monitoring the behavior of injected cells in terms of tissue dissemination and engraftment properties. Here, we app ...

American Chemical Society2017

Implications of short time scale dynamics on long time processes

Majed Chergui, Jean-Pierre Wolf, Ursula Röthlisberger, Luigi Bonacina, Cédric Schmidt, Siri Camee van Keulen, Swarnendu Bhattacharyya

2017

Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Stephanie Hwu, Solène Marcelle Françoise Marie Passemard, Davide Städler

Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented diagnostic applications as intra- and extra membrane contrast agents. Due to the relatively rece ...

Elsevier2015

Functionalized bismuth ferrite harmonic nanoparticles for cancer cells labelling and imaging

Sandrine Gerber, Luigi Bonacina, Giona Sonego, Solène Marcelle Françoise Marie Passemard, Davide Städler

Bismuth ferrite (BFO) harmonic nanoparticles (NPs) display high nonlinear optical efficiency and excellent biocompatibility profile which make them attractive for the development of diagnostic applications as contrast agents. In this study, we present a ge ...

Springer Verlag2015

Simultaneous Multi-Harmonic Imaging of Nanoparticles in Tissues for Increased Selectivity

Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Sébastien Courvoisier, Solène Marcelle Françoise Marie Passemard, Davide Städler

We investigate the use of Bismuth Ferrite (BFO) nanoparticles for tumor tissue labelling in combination with infrared multi-photon excitation at 1250 nm. We report the efficient and simultaneous generation of second and third harmonic by the nanoparticles. ...

Amer Chemical Soc2015

Nonlinear optical and magnetic properties of BiFeO3 harmonic nanoparticles

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Solène Marcelle Françoise Marie Passemard, Davide Städler

Second Harmonic Generation (SHG) from BiFeO3 nanocrystals is investigated for the first time to determine their potential as biomarkers for multiphoton imaging. Nanocrystals are produced by an auto-combustion method with 2-amino-2-hydroxymethyl-propane-1,3 ...

American Institute of Physics2014

Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Solène Marcelle Françoise Marie Passemard, Davide Städler

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, sele ...

Royal Society of Chemistry2014

Harmonic Nanoparticles for Regenerative Research

Jean-Pierre Wolf, Luigi Bonacina, Jérôme Extermann

In this visualized experiment, protocol details are provided for in vitro labeling of human embryonic stem cells (hESC) with second harmonic generation nanoparticles (HNPs). The latter are a new family of probes recently introduced for labeling biological ...

Journal Of Visualized Experiments2014

Tailoring single-cycle electromagnetic pulses in the 2–9 THz frequency range using DAST/SiO_2 multilayer structures pumped at Ti:sapphire wavelength

Jean-Pierre Wolf, Luigi Bonacina, Christoph Peter Hauri

We present a numerical parametric study of single-cycle electromagnetic pulse generation in a DAST/SiO2 multilayer structure via collinear optical rectification of 800 nm femtosecond laser pulses. It is shown that modifications of the thicknesses of the DA ...

Optical Society of America2014

Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

Sandrine Gerber, Luigi Bonacina, Phally Kong, Solène Marcelle Françoise Marie Passemard, Davide Städler

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end ...

Elsevier2013

Harmonic Nanocrystals for Bio-Labeling: a Survey of Optical Properties and Biocompatibility

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Rachid Hadji, Luigi Bonacina, Solène Marcelle Françoise Marie Passemard, Davide Städler, Jérôme Extermann

Nonlinear optical nanocrystals have been recently introduced as a promising alternative to fluorescent probes for multi-photon microscopy. We present for the first time a complete survey of the properties of the different nanomaterials proposed to date, de ...

American Chemical Society2012

Nonlinear Correlation Spectroscopy (NLCS)

Iwan Märki, Marcel Leutenegger, Theo Lasser, Jean-Pierre Wolf, Luigi Bonacina, Noelia Laura Bocchio, Stefan Geissbuehler

We present a novel concept for optical spectroscopy called nonlinear correlation spectroscopy (NLCS). NLCS analyses coherent field fluctuations of the second and third harmonic light generated by diffusing nanoparticles. Particles based on noncentrosymmetr ...

American Chemical Society2012

Spectral phase, amplitude, and spatial modulation from ultraviolet to infrared with a reflective MEMS pulse shaper

Nico de Rooij, Jean-Pierre Wolf, Fabio Jutzi, Wilfried Noell, Luigi Bonacina, Sébastien Lani, Jérôme Extermann

We describe the performance of a reflective pulse-shaper based on a Micro-ElectroMechanical System (MEMS) linear mirror array. It represents a substantial upgrade of a preceding release [Opt. Lett. 35, 3102 (2010)] as it allows simultaneous piston and tilt ...

Optical Society of America2011

Design, simulation, fabrication, packaging, and characterization of a MEMS-based mirror array for femtosecond pulse-shaping in phase and amplitude

Nico de Rooij, Jean-Pierre Wolf, Fabio Jutzi, Wilfried Noell, Luigi Bonacina, Sébastien Lani, Jérôme Extermann

We present an in-detail description of the design, simulation, fabrication, and packaging of a linear micromirror array specifically designed for temporal pulse shaping of ultrashort laser pulses. The innovative features of this device include a novel comb ...

American Institute of Physics2011

Time-Resolved Photodynamics of Triangular-Shaped Silver Nanoplates

Majed Chergui, Frank van Mourik, Luigi Bonacina, Camilla Bonati, Andrea Callegari

The authors measured the ultrafast response of triangular silver nanoparticles upon femtosecond excitation of their plasmon resonance. After a fast electron relaxation, the signature of a bimodal mech. vibration of the particle is apparent as a spectral mo ...

2006