Publications by Aleksandra Radenovic

Resolution in super-resolution microscopy – facts, artifacts, technological advancements and biological applications

Super-resolution microscopy (SRM) has undeniable potential for scientific discovery, yet still presents many challenges that hinder its widespread adoption, including technical trade-offs between resolution, speed and photodamage, as well as limitations in ...

The Company of Biologists2025

Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

Aleksandra Radenovic, Hilal Lashuel, Lely Feletti, Khalid Ashraf Mohie Ibrahim

The process of protein aggregation, central to neurodegenerative diseases like Huntington’s, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in disease ...

Springer Science and Business Media LLC2025

Sum-Frequency Scattering Spectroscopy Reveals the Charging Mechanism and Surface Structure of hBN Nanoflakes in Solution

Aleksandra Radenovic, Sylvie Roke, Li Zhang, Nathan Cyprien Arsène Ronceray, Benjamin Rehl

A molecular understanding of the interactions between two-dimensional (2D) layered materials and liquids is crucial for nanofluidics, catalysis, and solution-based 2D material processing. Among 2D materials, hexagonal boron nitride (hBN) has a number of ou ...

American Chemical Society (ACS)2025

Controlled Sensing of User-Defined Aptamer-Based Targets Using Scanning Ionic Conductance Spectroscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Barney Frederick Drake, Marcos Penedo Garcia, Helena Miljkovic, Wayne Yang Wen Wei, Zahra Ayar Dulabi

Solid-state nanopores offer the possibility of detecting disease biomarkers in early diagnostic applications. Standard approaches harness fingerprinting, where protein targets are bound to DNA carriers and detected in free translocation with a solid-state ...

2025

Assessment of neurobehavioural traits under gnotobiotic conditions: an approach for multiple analyses in the same mouse

Aleksandra Radenovic, Raphaël Doenlen, Arielle Louise Planchette

The gut-microbiota-brain axis influences neuroinflammation, neural development and behaviour such as sociability, memory and anxiety. To study these traits in vivo, especially during development or disease, it is crucial to analyse them over time and with ...

2025

Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera

Claudio Bruschini, Edoardo Charbon, Aleksandra Radenovic, Matteo Dal Peraro, Nathan Cyprien Arsène Ronceray

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to discriminate fluorescent molecules or probe their nanoscale environment. Traditionally, FLIM uses time-correlated single-photon counting (TCSPC), which is precise but intrinsically low-t ...

2025

Fast Tracking with SPADs from Binary 1-Bit Per Pixel Output: Single-Photon Single-Particle Tracking

Aleksandra Radenovic, Nathan Cyprien Arsène Ronceray

Oxford University Press (OUP)2025

Open-source microscope add-on for structured illumination microscopy

Matthias Lütolf, Theo Lasser, Aleksandra Radenovic, John McKinney, Georg Fantner, Olivier François Venzin, Mélanie Thérèse Marie Hannebelle, Tomas Lukes, Samuel Mendes Leitão, Antonius Chrisnandy, Chiara Toniolo, Andrew Charles Oates, Prabhu Prasad Swain, Nathan Cyprien Arsène Ronceray

Super-resolution techniques expand the abilities of researchers who have the knowledge and resources to either build or purchase a system. This excludes the part of the research community without these capabilities. Here we introduce the openSIM add-on to ...

Nature Portfolio2024

Nanofluidic logic with mechano-ionic memristive switches

Andras Kis, Aleksandra Radenovic, Théo Denis Tobias Emmerich, Andrey Chernev, Nathan Cyprien Arsène Ronceray, Edoardo Lopriore, Yunfei Teng, Vasily Artemov

Neuromorphic systems are typically based on nanoscale electronic devices, but nature relies on ions for energy-efficient information processing. Nanofluidic memristive devices could thus potentially be used to construct electrolytic computers that mimic th ...

Nature Portfolio2024

CVD graphene contacts for lateral heterostructure MoS2 field effect transistors

Andras Kis, Aleksandra Radenovic, Zhenyu Wang

Intensive research has been carried out on two-dimensional materials, in particular molybdenum disulfide, towards high-performance field effect transistors for integrated circuits 1 . Fabricating transistors with ohmic contacts is a challenging task due to ...

Nature Portfolio2024

Improvement of DERA activity and stability in the synthesis of statin precursors by immobilization on magnetic nanoparticles

Aleksandra Radenovic, Andrey Chernev

Higher stability and hyperactivation of the DERA enzyme were achieved by covalent bonding to magnetic nanoparticles with succinic anhydride as an activating agent. ...

Royal Society of Chemistry (RSC)2024

Label-Free Imaging of DNA Interactions with 2D Materials

Aleksandra Radenovic, Suliana Manley, Jenny Sülzle, Nathan Cyprien Arsène Ronceray, Yuta Shimoda, Eveline Simone Mayner, Wayne Yang Wen Wei

Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their properties can be engineered to tune interactions between the surface and biomolecules. Yet, not many methods can measure these interactions in a liquid environme ...

2024

Fluorescence microscopy: A statistics-optics perspective

Aleksandra Radenovic

Fundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Accounting for these features is often critical in quantitatively interpreting microscopy images, especially those gathering information at scal ...

Amer Physical Soc2024

Nature-inspired stalactite nanostructures such as nanopores for biosensing and energy harvesting

Aleksandra Radenovic, Andrey Chernev, Yunfei Teng

A method of forming a structure, preferably a pore, comprises the steps of providing a template comprising at least one template aperture, and growing at least one material at an orifice of the template aperture by depositing the material, whereby the stru ...

2024

Resolution in super-resolution microscopy — definition, trade-offs and perspectives

Aleksandra Radenovic, Suliana Manley

Super-resolution microscopy (SRM) is gaining popularity in biosciences; however, claims about optical resolution are contested and often misleading. In this Viewpoint, experts share their views on resolution and common trade-offs, such as labelling and pos ...

2024

Monitoring Electrochemical Dynamics through Single-Molecule Imaging of hBN Surface Emitters in Organic Solvents

Aleksandra Radenovic, Martina Lihter, Nathan Cyprien Arsène Ronceray, Tzu-Heng Chen, Eveline Simone Mayner

Electrochemical techniques conventionally lack spatial resolution and average local information over an entire electrode. While advancements in spatial resolution have been made through scanning probe methods, monitoring dynamics over large areas is still ...

2024

Label-Free Techniques for Probing Biomolecular Condensates

Aleksandra Radenovic, Khalid Ashraf Mohie Ibrahim, Helena Miljkovic, Wayne Yang Wen Wei, Akhil Sai Naidu

Biomolecular condensates play important roles in a wide array of fundamental biological processes, such as cellular compartmentalization, cellular regulation, and other biochemical reactions. Since their discovery and first observations, an extensive and e ...

Amer Chemical Soc2024

A large-scale integrated vector–matrix multiplication processor based on monolayer molybdenum disulfide memories

Andras Kis, Aleksandra Radenovic, Zhenyu Wang, Guilherme Migliato Marega, Mukesh Kumar Tripathi, Gabriele Pasquale

Data-driven algorithms—such as signal processing and artificial neural networks—are required to process and extract meaningful information from the massive amounts of data currently being produced in the world. This processing is, however, limited by the t ...

2023

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Aleksandra Radenovic, Jérôme Waser, Beat Fierz, Xingyu Liu, Nathan Cyprien Arsène Ronceray, Wei Cai

Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are of high importance for medicinal chemistry. Herein, we report the first gold(I)-catalyzed macrocyclization of peptide-EBXs (ethynylbenziodoxolones) via C2-Trp C–H ...

2023

The Three-Phase Contact Potential Difference Modulates the Water Surface Charge

Aleksandra Radenovic, Andrei Kiselev, Roman Doronin, Vasily Artemov

The surface charge of an open water surface is crucialfor solvationphenomena and interfacial processes in aqueous systems. However, themagnitude of the charge is controversial, and the physical mechanismof charging remains incompletely understood. Here we ...

AMER CHEMICAL SOC2023