Publications by Sai Reddy | EPFL Graph Search

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Sai Reddy, Patricia Corthésy Henrioud, Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Fabian Sesterhenn, Che Yang, Pablo Gainza Cirauqui, Sabrina Susan Vollers, Stéphane Rosset

Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...

2019

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2011

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Sai Reddy

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy, Eleonora Simeoni

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

Sai Reddy

The emergence of recombinant DNA technology has shifted research towards developing subunit vaccines, which use protein or peptide antigens instead of live/attenuated pathogens. Recent research has also shown that the best way to get sustained immunity is ...

EPFL2008

Lymphatic drainage function and its immunological implications: From dendritic cell homing to vaccine design

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic capillaries provides transport of macromolecular nutrients to cells in the interstitium. We discuss herein how this flow also provides continuous access to immune ce ...

Elsevier2008

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

2008

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

Nature Publishing Group2007

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles

Melody Swartz, Sai Reddy

Effective interstitial transport of particles is necessary for injected drug/diagnostic agents to reach the intended target; however, quantitative methods to estimate such transport parameters are lacking. In this study we develop an in vivo model for eval ...

2006

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles

Annemie Rehor, Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. This study investigates the delivery of 20, 45, and 100nm diameter poly(ethylene glycol)-stabilized poly(propyl ...

2006

Targeting dendritic cells with biomaterials: developing the next generation of vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Current vaccine and immunotherapy technology faces ongoing challenges in both efficacy and practicality: many chronic diseases cannot yet be addressed by vaccination, and several vaccines that do function well require multiple injections, which is a substa ...

2006